%0 Journal Article %T Agentes Biol¨®gicos en el tratamiento de la Artritis Reumatoide %A D¨ªaz-Coto %A Jos¨¦ Francisco %A Monge-Zeled¨®n %A Pablo %A Brenes-Silesky %A Francisco %A Arias-Howlett %A Christian %J Acta M¨¦dica Costarricense %D 2011 %I Scientific Electronic Library Online %X a better understanding of the immuno-pathological rheumatoid arthritis enabled by sophisticated molecular technology to develop antagonists against specific targets in various steps of the immune pathogenesis of the disease. there is ample evidence on the efficacy, tolerability and safety of these agents in different clinical scenarios of rheumatoid arthritis. the introduction of biological agents in the armamentarium of rheumatoid arthritis has marked a milestone in its evolution and prognosis rheumatoid arthritis. %K rheumatoid arthritis %K patients %K disease %K therapy. %U http://www.scielo.sa.cr/scielo.php?script=sci_abstract&pid=S0001-60022011000500005&lng=en&nrm=iso&tlng=en