%0 Journal Article
%T Influenza pand¨ºmica A/H1N1: an¨¢lise comparativa de altera£¿£¿es histopatol¨®gicas pulmonares
%A Marchiori
%A Roberta
%A Bredt
%A Carla Sakuma de Oliveira
%A Campos
%A Marcos Menezes Freitas de
%A Negretti
%A F¨¢bio
%A Duarte
%A P¨¦ricles Almeida Delfino
%J Einstein (S£¿o Paulo)
%D 2012
%I Instituto Israelita de Ensino e Pesquisa Albert Einstein
%R 10.1590/S1679-45082012000300009
%X objective: to analyze the histopathological lung findings of four fatal cases of the 2009 h1n1 influenza pandemic and their correlation with clinical and epidemiological characteristics. methods: descriptive data from medical records of four patients who died in the intensive care unit of a university hospital in 2009. nasopharyngeal aspirate specimens were collected from the patients and were analyzed by real-time polymerase chain reaction. lung biopsy was performed post mortem; a score of intensity for pathological changes was applied. results: three patients had positive real-time polymerase chain reaction (although all of them had a clinical diagnose of influenza h1n1). the main histopathological changes were: exudative diffuse alveolar damage with atelectasis; varying degrees of alveolar hemorrhage and edema, necrosis and sloughing of the respiratory epithelium in several bronchioli; and thrombus formation. one of the patients (the pregnant one) presented histopathological findings of cytomegalic inclusion. conclusion: the pulmonary histopathological findings in patients with fatal 2009 h1n1 influenza pandemic disclosed intense alveolar damage and hemorrhage and severe bronchiolitis. a co-infection with cytomegalovirus was described in the pregnant patient.
%K influenza a virus
%K h1n1 subtype
%K pandemics
%K intensive care units.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1679-45082012000300009&lng=en&nrm=iso&tlng=en