%0 Journal Article
%T SYNTHESIS AND CYTOTOXIC ACTIVITY OF GERANYLMETHOXYHYDROQUINONE DERIVATIVES
%A Baeza Maturana
%A Evelyn
%A Catal¨¢n Mar¨ªn
%A Karen
%A Villena Garc¨ªa
%A Joan
%A Carrasco Altamirano
%A H¨¦ctor
%A Cuellar Fritis
%A Mauricio
%A Espinoza Catal¨¢n
%A Luis
%J Journal of the Chilean Chemical Society
%D 2012
%I Scientific Electronic Library Online
%R 10.4067/S0717-97072012000300005
%X the new synthetic geranyl-2,4-methoxyhydroquinone 1 and the known geranyl-4,5-methoxyhydroquinone 2 were prepared by electrophilic aromatic substitution (eas) reactions between geraniol and 1,3,5-trimethoxyphenol using bf3¡¤et2o as a catalyst. furthermore, the new geranylmethoxyhydroquinones derivatives (3-6) were obtained by chemical transformations of 1 and 2. the compounds have been evaluated for their cytotoxic activities against pc-3 human prostate cancer cell line, mcf-7 and mda-mb-231 human breast cancer cells lines and dermal human fibroblasts dhf. ic50 values for compounds 1 and 5 ranged in the 80 ¦Ìm level.
%K geranylmethoxyhydroquinone
%K synthesis
%K cytotoxic activity.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-97072012000300005&lng=en&nrm=iso&tlng=en