%0 Journal Article
%T SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES
%A AGANAGOWDA
%A GADADA
%A THAMYONGKIT
%A PATCHANITA
%A PETSOM
%A AMORN
%J Journal of the Chilean Chemical Society
%D 2012
%I Scientific Electronic Library Online
%R 10.4067/S0717-97072012000100019
%X 3-chlorobenzothiophene-2-carbonyl chloride 1 was reacted with 4-aminoacetophenone in acetone to give compound 2. in order to prepare chalcones 3a-d, compound 2 was condensed with various aldehydes in the presence of koh in dmf. these chalcones 3a-d on cyclization with urea, thiourea, hydroxylamine hydrochloride, phenyl hydrazines and hydrazine hydrate gave the corresponding oxapyrimidines 4a-d, isoxazolines 5a-d, pyrazoles 6a-h, pyrazolines 7a-d and thiopyrimidines 8a-d, respectively. the structures of all the synthesized compounds were confirmed by spectral data and had been screened for antibacterial activity.
%K benzothiophene
%K isoxazolines
%K pyrimidines
%K pyrazolines
%K antimicrobial activity.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-97072012000100019&lng=en&nrm=iso&tlng=en