%0 Journal Article
%T SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE
%A JOSHI
%A SHEELA
%A BILGAIYAN
%A PURTI
%A PATHAK
%A ANJU
%J Journal of the Chilean Chemical Society
%D 2012
%I Scientific Electronic Library Online
%R 10.4067/S0717-97072012000300017
%X a series of biologically active mannich bases with heteroaromatic ring system have been synthesized employing mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy}methyl] 6-9 dihydro-3h-purin-6-one ( potent drug) with biologically active sulphonamides and secondary amines. they were analyzed by elemental analysis and characterized by spectral studies- uv, ir, 1h nmr, powder x-ray diffraction and scanning electron microscopy. the mannich bases were screened for their antibacterial activity against various gram + and gram - bacteria. the results had shown that the mannich bases are quiet active against pathogens under study at varying concentrations. the toxicity of synthesized mannich bases was ascertained by ld50 test.
%K 2-amino-9 [{(1
%K 3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3h-purin-6-one (ganciclovir)
%K sulphonamides
%K mannich reaction
%K mannich bases
%K antibacterial activity
%K ld50 test.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-97072012000300017&lng=en&nrm=iso&tlng=en