%0 Journal Article
%T SYNTHESIS AND AChE INHIBITING ACTIVITY OF 2, 4 SUBSTITUTED 6-PHENYL PYRIMIDINES
%A PAZ
%A CRISTIAN
%A PETER
%A MARTIN G
%A SCHMIDT
%A BERND
%A BECERRA
%A JOSE
%A GUTI¨¦RREZ
%A MARGARITA
%A ASTUDILLO
%A LUISA
%A SILVA
%A MARIO
%J Journal of the Chilean Chemical Society
%D 2012
%I Scientific Electronic Library Online
%R 10.4067/S0717-97072012000300020
%X novel substituted pyrimidines were synthesized from methyl 2,4-dioxo-4-phenyl-butanoate (i-a) and urea, followed by mitsunobu coupling of i-a with benzyl or allyl alcohol to give the corresponding 2-hydroxypyrimidine ethers in good yields. saponification of i-a, followed by reaction with benzyl or allyl amines in the presence of tbtu yielded 2-hydroxy-6-phenyl-pyrimidine 4-carboxamides. ache and buche assays revealed 2-hydroxy-6-phenyl-pyrimidine-4-carboxyallyamide as the most active compound, ic50= 90 ¦Ěm, with no inhibition of buche.
%K pyrimidines
%K inhibition ache
%K mitsunobu
%K tbtu.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-97072012000300020&lng=en&nrm=iso&tlng=en