%0 Journal Article
%T NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
%A WARDAKHAN
%A WAGNAT WAHBA
%A SAMIR
%A EMAN MOHAMED
%J Journal of the Chilean Chemical Society
%D 2012
%I Scientific Electronic Library Online
%R 10.4067/S0717-97072012000200013
%X the hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. the latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. the antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (mcf-7), non-small cell lung cancer (nci-h460) and cns cancer (sf-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.
%K hydrazide-hydrazone
%K pyridazine
%K 1
%K 2
%K 3-triazole
%K pyrazole
%K anti-tumor.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-97072012000200013&lng=en&nrm=iso&tlng=en