%0 Journal Article
%T BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
%A CA£żETE
%A A
%A ARMIJO
%A F
%A DEL VALLE
%A M. A
%A TAPIA
%A R.A
%A THEODULOZ
%A C
%A PESSOA
%A C. D
%A CANTUARIAS
%A L
%A RECABARREN
%A G
%J Journal of the Chilean Chemical Society
%D 2012
%I Scientific Electronic Library Online
%R 10.4067/S0717-97072012000200015
%X we report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (ags), lung (sk-mes-1), bladder (j82) cancer cell lines and human normal lung fibroblasts (mcr-5). two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (ags) cell lines and human normal lung fibroblasts (mcr-5). the quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.
%K quinone
%K electrochemical properties
%K antiproliferative activity.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-97072012000200015&lng=en&nrm=iso&tlng=en