%0 Journal Article
%T Angiog¨Śnesis neopl¨˘sica
%A Khosravi Shahi
%A P.
%A Castillo Rueda
%A A. del
%A P¨Śrez Manga
%A G.
%J Anales de Medicina Interna
%D 2008
%I Scientific Electronic Library Online
%R 10.4321/S0212-71992008000700012
%X neoplastic angiogenesis is an essential process in the progressive growth of neoplasms and the production of metastasis. angiogenesis consists of a series of linked and sequential steps that ultimately leads to the development of a neovascular blood supply to the tumor mass. vegf has got an essential role in neoplastic angiogenesis, therefore it is an important target in the treatment of neoplasms. bevacizumab, a humanized monoclonal antibody, inhibits vegf, and may also improve the delivery of chemotherapy to the tumor mass. multi-kinase ihibitors (sorafenib and sunitinib) are orally administered small-molecules, that inhibit different receptors (essentials in the neoplastic angiogenesis), such as the vegfr or pdgfr. these agents are useful in the treatment of advanced renal-cell carcinoma, and are under investigation in several tumors.
%K cancer
%K vegf
%K bevacizumab
%K sorafenib
%K sunitinib.
%U http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0212-71992008000700012&lng=en&nrm=iso&tlng=en