%0 Journal Article
%T Enfermedad de Kikuchi Fujimoto
%A Corral
%A Mariquena
%A Huergo
%A In¨¦s
%A Alianak
%A Marina
%A Staffieri
%A Florencia
%A Fainberg
%A Ana
%A Staffieri
%A Fernando
%J Medicina (Buenos Aires)
%D 2012
%I Fundaci¨®n Revista Medicina
%X kikuchi-fujimoto disease or histiocytic necrotizing lymphadenitis is a rare, benign, self-limited condition of unknown etiology. a 16-year-old woman with no relevant clinical history seeks medical attention for fever and cervical adenopathies. in a physical examination the patient is found to be febrile (38.5 ˇăc) with multiple bilateral, hard-elastic cervical adenopathies, congestive oropharynx and mild splenomegaly with no other relevant pathological findings. the laboratory examination shows signs of pancytopenia and an increase in the erythrocyte sedimentation rate, ¦Â2-microglobulin, transaminases and lactate dehydrogenase. several serological tests are carried out with negative results except for immunoglobulin g for parvovirus, which is positive. a computerized axial tomography scan of head, neck, thorax, abdomen and pelvis shows bilateral lateral cervical adenomegalies (the largest with a size of 15 mm) and bilateral axillary adenomegalies of less than 10 mm in diameter; small basal lung condensations with mild pleural effusion, mild homogeneous splenomegaly, and a small amount of free fluid in the abdominal cavity at the bottom of the douglas cul-de-sac. possible respiratory and gynecological infections are treated with ampicillin/sulbactam together with doxycycline. the patient progresses with persistence of the symptoms. a lymph node biopsy is then performed, revealing a morphology compatible with kikuchi-fujimoto disease. treatment with prednisone is initiated with a clinical and laboratory improvement in the patient's condition. kikuchi-fujimoto disease is probably under-reported and under-diagnosed due to the low index of suspicion. greater awareness of this illness would result in clinicians arriving at this diagnosis more often.
%K kikuchi-fujimoto disease
%K histiocytic necrotizing lymphadenitis
%K fever
%K cervical adenopathies.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802012000100008&lng=en&nrm=iso&tlng=en