%0 Journal Article
%T La etiolog¨ªa de la esquizofrenia
%A Gejman
%A Pablo V.
%A Sanders
%A Alan R.
%J Medicina (Buenos Aires)
%D 2012
%I Fundaci¨®n Revista Medicina
%X research conducted in recent years represents a new dawn of knowledge for the risk factors of schizophrenia, and genome-wide approaches have revolutionized the field of genetic mapping of schizophrenia. the aggregate genetic data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polygenic inheritance, and a genetic overlap (pleiotropy) of schizophrenia and other psychiatric disorders, such as bipolar disorder and autism. a main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia. the current and upcoming resequencing programs - both exomes (all exons) and full genomes - and genome-wide transcriptional analyses will allow a more thorough dissection of the molecular genetics of the disorder.
%K schizophrenia
%K genetics
%K genome
%K etiology
%K snp
%K cnv
%K polygenic
%K gwas
%K epidemiology.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802012000300007&lng=en&nrm=iso&tlng=en