%0 Journal Article
%T Ventajas y desventajas de los distintos tipos de anfotericina en pediatr¨ªa: revisi¨®n de la bibliograf¨ªa
%A Bes
%A David F
%A Sberna
%A Norma
%A Rosanova
%A Mar¨ªa Teresa
%J Archivos argentinos de pediatr£¿-a
%D 2012
%I Sociedad Argentina de Pediatria
%R 10.5546/aap.2012.46
%X fungal infections have increased in morbidity, and the range of fungal species causing disease in humans has expanded, mainly due to the rise in number of immunocompromised patients. am-photericin b is a broad spectrum antifungal agent that has been the standard therapy for many life-threatening mycoses for the past 50 years. however, the use of this drug is commonly associated with infusion related events (such as chills, fever, headache, nausea, vomiting), and most signif-cantly to dose limiting nephrotoxicity. three lipid formulations that increase the therapeutic index have been approved for use. however, questions regarding dose, cost-effectiveness and indications exist in the pediatric setting. although no high quality evidence studies in children comparing the four types of amphotericin in culture-positive fungal infections currently exist, all four preparations are believed to have similar effectiveness. high drug costs limit the use of lipid formulations; however, renal toxic side effects should be taken into account when costs are considered.
%K amphotericin
%K side effects
%K toxicity
%K children
%K pharmacoeconomics
%K kidney.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0325-00752012000100010&lng=en&nrm=iso&tlng=en