%0 Journal Article
%T Intervalos de referencia para tirotropina s¨¦rica durante los primeros 14 d¨ªas de vida
%A Yaniskowski
%A Mar¨ªa Lucy
%J Archivos argentinos de pediatr£¿-a
%D 2012
%I Sociedad Argentina de Pediatria
%R 10.5546/aap.2012.27
%X introduction. early detection of congenital hy-pothyroidism (ch) prevents impaired cognitive and motor development at problems. to increase the screening program specifcity, we defned reference intervals for serum tsh in newborns between 2 and 14 days of life. patients and methods. newborn infants from our neonatal screening program between 2001 and 2007. serum tsh was determined by elec-trochemiluminescence. there were excluded neonates who died before the frst month of life or with less than 1500 grams at birth, samples with tsh <0,01 ¦̀u/ml., processed after 14 days of life and from other medical centers. statistical tools: student t-tests, measures of centrality and dispersion, and logarithmic transformations. results. studied population: 6772 newborn infants out of 7869, 50.49% were males. the male/ female ratio was similar during the 14 days. the mean age at testing was 5.85 days (¡À 2.58), and the mean of tsh value was 4.42 ¦̀u/ml (¡À 4.17). inverse relationship was found between age and tsh (mean tsh at days 2 and 14 was 5.82 ¦̀u/ ml and 2.58 respectively). conclusion. we found statistical evidence on an inverse relationship between tsh and age in newborn infants whit 14 days of age. reference intervals for tsh contribute to a better assessment of thyroid status in neonates and to defne an appropriate conduct for individual therapy.
%K serum thyotropin
%K reference intervals
%K neonatal period.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0325-00752012000100007&lng=en&nrm=iso&tlng=en