%0 Journal Article
%T Aspectos inmunol¨®gicos en la enfermedad de Parkinson
%A Gonz¨¢lez-Torres
%A Laura Clementina
%A Armend¨¢riz-Borunda
%A Juan
%J Archivos de neurociencias (M¨¦xico, D.F.)
%D 2005
%I Scientific Electronic Library Online
%X parkinson disease is a neurodegenerative disorder that affects 50/100,000 individuals in mexico. parkinson disease is characterized by reduction in dopamine content of the substancia nigra pars compacta resulting in 1055 of domamine-containing neurons. the postulated cause of the disease includes several processes: 1. a growth factor deficiency, such as nerve growth factor and brain-derived neurotrophic factor, cytokines which can prevent and protect neuronal cell death; which may regulate glial phenotype, t lymphocytes and blymphocytes functions, and the surviving pathway signals; 2. dysfunction of the ubiquitin-proteasome system related to the histophatology of this disease; and 3. excitotoxic mechanisms, resulting in information of free radicals and the neuroinflammatory processes leading to autoimmunity or a failing immune response.
%K parkinson
%K neuroinflammation
%K immunity
%K neurotrophins.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S0187-47052005000300009&lng=en&nrm=iso&tlng=en