%0 Journal Article
%T Variabilidade da frequ¨ºncia card¨ªaca em pacientes com Distrofia Miot£¿nica tipo 1
%A Fregonezi
%A Guilherme
%A Ara¨²jo
%A Thaise
%A Dourado Junior
%A Mario Emilio
%A Ferezini
%A Joceline
%A Silva
%A Ester
%A Resqueti
%A Vanessa
%J Arquivos Brasileiros de Cardiologia
%D 2012
%I Sociedade Brasileira de Cardiologia - SBC
%R 10.1590/S0066-782X2012005000021
%X background: cardiac involvement is common in myotonic dystrophy (md) patients. heart rate variability (hrv) is a simple and reliable technique that can be useful for studying the influence of the autonomic nervous system on the heart. objective: study heart rate variability in patients with type 1 md. methods: we studied hrv during 5-minute recordings in md patients and in a healthy control group. we analyzed frequency domains (lf and hf) in normalized units (nu) and sympathovagal balance, in the sitting and supine position. results: seventeen patients (10 men and 7 women) and seventeen matched healthy individuals (10 men and 7 women) were studied. sympathetic and parasympathetic modulations of the heart increased in male md patients from supine to sitting position in 19% of lfnu and the lf/hf ratio rose by 42.3%. in the sitting position, male md patients exhibited significantly higher sympathovagal balances in 50.9% compared to healthy control individuals. hrv was influenced by both gender and disease. gender influenced lfnu in the supine position while the lf/hf ratio and hfnu were affected in both positions. post hoc analyses showed that gender significantly impacts md patients and healthy individuals in different ways (p < 0.01). the low frequency domain in the sitting position (lfnu) was significantly influenced by the disease. conclusion: the results of this study suggest that the sympathetic drive in middle-aged male md patients who are not severely impaired and present moderate disease duration seems to be greater than in healthy matched individuals.
%K heart rate
%K myotonic dystrophy
%K spectrum analysis
%K autonomic nervous system.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0066-782X2012000400010&lng=en&nrm=iso&tlng=en