%0 Journal Article
%T Mutation rate of 7 X-STRs of common use in population genetics
%A Glesmann
%A Laura A.
%A Martina
%A Pablo F.
%A Vidal Rioja
%A Lidia
%A Catanesi
%A Cecilia I.
%J BAG. Journal of basic and applied genetics
%D 2009
%I Scientific Electronic Library Online
%X microsatellite loci analysis is a relevant tool in population genetic studies and also in paternity testing. in this field the x-chromosome str loci are widely used for female offspring testing but their mutation rates are scarcely known. in this work we performed a mutation rate analysis of seven str markers located in the x- chromosome specific region, in mother-son pairs and father-mother-daughter trios. among 1015 allele transfers, we found only one change for a mother-daughter transmission in the dxs9898 locus, consisting of a loss of one single repeat. this finding allowed us to estimate a general mutation rate of ¦Ì=9.85 x 10-4 (2.49 x 10-4 - 5.49 x 10-2) which can be applied to population studies. this value is consistent with other reports on autosomal str loci, suggesting that similar molecular mechanisms are acting on x and autosomal repetitive markers.
%K x chromosome
%K str
%K mutation rate
%K population genetics.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S1852-62332009000200002&lng=en&nrm=iso&tlng=en