%0 Journal Article
%T Effect of thymosin alpha-1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro
%A Yang
%A Xia
%A Qian
%A Feng
%A He
%A Hai-Yang
%A Liu
%A Kai-Jun
%A Lan
%A Yuan-Zhi
%A Ni
%A Bing
%A Tian
%A Yi
%A Fu
%A Xiao-Lan
%A Zhang
%A Ji
%A Shen
%A Zi-Gang
%A Li
%A Jian
%A Yin
%A Yi
%A Li
%A Jin-Tao
%A Wu
%A Yu-Zhang
%J Brazilian Journal of Medical and Biological Research
%D 2012
%I Associa??o Brasileira de Divulga??o Cient¨ªfica
%R 10.1590/S0100-879X2011007500159
%X thymosin alpha 1 (t¦Á1) has been shown to have beneficial effects on numerous immune system parameters, but little is known about the effects of t¦Á1 on patients with gastric carcinoma. the objective of this study was to determine the effect of t¦Á1 on subpopulations of th1, th2, th17, and regulatory t cells (tregs) in vitro, and to evaluate its efficacy as an immunoregulatory factor in patients with gastric carcinoma. we compared the effect of t¦Á1 on the frequency of cd4+ and cd8+ t cells, especially the cd4+cd25+foxp3+ tregs in peripheral blood mononuclear cells (pbmcs) from gastric carcinoma patients (n = 35) and healthy donors (n = 22). we also analyzed the changes in the proliferation of pbmcs in response to treatment with t¦Á1, and examined the production of th1, th2, and th17 cytokines by pbmcs and tumor-infiltrating lymphocytes. the treatment of pbmcs from gastric cancer patients, with t¦Á1 (50 ¦Ìg/ml) alone increased the percentage of cd4+cd25+foxp3+ (suppressive antitumor-specific tregs) from 1.68 ¡À 0.697 to 2.19 ¡À 0.795% (p < 0.05). our results indicate that t¦Á1 increases the percentage of tregs and il-1¦Â, tnf-¦Á, and il-6 in vitro.
%K t¦Á1
%K gastric carcinoma
%K tregs
%K th1
%K th2
%K th17.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2012000100005&lng=en&nrm=iso&tlng=en