%0 Journal Article
%T Carcinoma neuroendocrino de c¨¦lulas grandes de pulm¨®n: an¨¢lisis de una serie de once casos en un hospital universitario
%A Garc¨ªa G¨®mez
%A R.
%A ¨¢lvarez Fern¨¢ndez
%A E.
%A Gonz¨¢lez Aragoneses
%A F.
%A Cebollero Presmanes
%A M.
%A Moreno
%A N.
%A Arranz Arija
%A J. A.
%A Abad
%A G.
%A Siso
%A I.
%A Iglesias
%A L.
%A Pach¨®n
%A V.
%A D¨ªaz
%A V.
%A Khosravi
%A P.
%A P¨¦rez Manga
%A G.
%J Oncolog¨ªa (Barcelona)
%D 2006
%I Scientific Electronic Library Online
%R 10.4321/S0378-48352006000800002
%X purpose: lung carcinomas with neuroendocrine differentiation are a heterogeneous group of tumors related to typical and atypical carcinoids, neuroendocrine large-cell carcinomas (nlcc) and small-cell lung cancer (sclc). nlcc comprises less than 5% of non small-cell lung cancer (nsclc). in this report, we describe a series of nlcc treated in a single institution in the last ten years. material and methods: eleven patients diagnosed as having nlcc (5 of them with mixed histology). results: at diagnosis, the mean age of the patients was 66 years (5 males and 6 females); 4 had localized disease, 5 locally advanced disease, and 2 metastatic disease. seven patients underwent initial radical surgery (2 of them followed by adjuvant chemotherapy), 1 patient received chemotherapy and radiotherapy, and 3 patients only chemotherapy. median overall survival for the whole series was 24 months, and the overall 2-year and 5-year survival were 45% and 27% respectively. conclusion: our data corroborate the general recommendation of treating nlcc in a similar way as the rest of the non small-cell lung cancer (nsclc) are treated. radical surgery is the main treatment for localized tumors. there are no data indicating a worse response of these tumors to radiation therapy or chemotherapy.
%K large-cell lung cancer
%K neuroendocrine differentiation.
%U http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0378-48352006000800002&lng=en&nrm=iso&tlng=en