%0 Journal Article
%T Characterization and in vitro release of cyclosporine-A from poly(D,L-lactide-co-glycolide implants obtained by solvent/extraction evaporation
%A Saliba
%A Juliana Barbosa
%A Silva-Cunha Junior
%A Armando da
%A Silva
%A Gisele Rodrigues da
%A Yoshida
%A Maria Irene
%A Mansur
%A Alexandra Ancelmo Piscitelli
%A Mansur
%A Herman Sander
%J Qu¨Şmica Nova
%D 2012
%I Sociedade Brasileira de Qu¨Şmica
%R 10.1590/S0100-40422012000400013
%X cyclosporine-a-loaded plga implants were developed intended for ocular route. implants were prepared using solvent extraction/evaporation technique followed by casting of the cake into rods in a heated surface. xrd patterns showed that cyclosporine-a was completely incorporated into plga. ftir and dsc results indicated alterations on drug molecular conformation aiming to reach the most stable thermodynamic conformation at polymer/drug interface. implants provided controlled/sustained in vitro release of the drug. during the first 7 weeks, the drug release was controlled by the diffusion of the cyclosporine-a; and between 7-23 week period, the drug diffusion and degradation of plga controlled the drug release.
%K cyclosporine-a
%K poly(d
%K l-lactide-co-glycolide) (plga)
%K biodegradable intraocular implant.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422012000400013&lng=en&nrm=iso&tlng=en