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The Journal of Clinical Investigation

ISSN Print: 0021-9738

ISSN Online:

主页: https://www.jci.org/archive?utf8=%E2%9C%93&volume=128

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The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity

A. Simonne Paine,Colleen Notley,Cyrill Géraud,David Lillicrap,Ilinca Georgescu,Jeff Mewburn,Jesse D. Lai,Julia Kzhyshkowska,Kai Schledzewski,Kate Nesbitt,Laura L. Swystun,Paula D. James,Robert R. Montgomery,Sergij Goerdt,Wilma Hopman

Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy

Ana Aparicio,Hao Zhao,Irina Apostolou,James P. Allison,Jan Zhang,Jill Skepner,Liangwen Xiong,Padmanee Sharma,Patrick Trojer,Sangeeta Goswami,Sumit K. Subudhi,Swetha Anhan,Xuejun Zhang

OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity

Alessia Chiorazzi,Alex Sparreboom,Alice A. Gibson,Alix F. Leblanc,Guido Cavaletti,Jason A. Sprowl,Kevin M. Huang,Kristen W. Hong,Lara E. Sucheston-Campbell,Marissa S. Pioso,Maryam B. Lustberg,Mingqing Chen,Olivia Costa,Paola Alberti,Peter de Bruijn,Raquel E. Reinbolt,Ron H. Mathijssen,Shuiying Hu,Tatiana Florea,Vamsi Chodisetty,W. David Arnold

The evolving landscape of predictive biomarkers of response to PARP inhibitors

Anish Thomas,Junko Murai,Yves Pommier

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Andrew G. Brooks,Bernard A. Lafont,Bruce D. Walker,David A. Price,David W. Haas,Emma Gostick,Florencia P. Segal,Jacqueline Widjaja,Jacques Fellay,James J. Goedert,Jamie Rossjohn,Jonathan M. Carlson,Julian P. Vivian,Mark Connors,Mary Carrington,Maureen P. Martin,Nelson Michael,Nicolas Vince,Patrick R. Shea,Philippa M. Saunders,Phillip Pymm,Rasmi Thomas,Shu Cheng Wong,Sian Llewellyn-Lacey,Stephen A. Migueles,Steven G. Deeks,Steven M. Wolinsky,Veron Ramsuran,Vivek Naranbhai,Xiaojiang Gao,Ying Qi,Zabrina L. Brumme

Redirection to the bone marrow improves T cell persistence and antitumor functions

Angelika Holler,Anjum B. Khan,Barry Flutter,Ben Carpenter,Calum Forrest,Clare L. Bennett,Constina Pospori,Cristina Lo Celso,Emma Morris,Hans Stauss,James Griffin,Maryam Ahmadi,Mathias Zech,Pedro Santos e Sousa,Pedro Velica,Reema Khorshed,Ronjon Chakraverty,Sara Ghorashian,Sara Gonzalez Anton,Sharyn Thomas,Terry K. Means,Zaida Ramirez-Ortiz

Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury

Anastasia Soulas,Anthony J. Kanai,H. Francis Farhadi,Irina Zabbarova,Jae Cheon Ryu,Katharine Tooke,Margaret A. Vizzard,Mitsuharu Yoshiyama,Nabila Saidi,Nisha Ganesh,Stephanie Daugherty,Sung Ok Yoon,Susan E. Malley,Tirzah Weiss,Uri Saragovi,William C. de Groat,Youko Ikeda

Therapeutic potential of carbonyl-scavenging carnosine derivative in metabolic disorders

Jacob M. Haus John P. Thyfault

Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer

Atsushi Goda,Futoshi Akiyama,Ichiro Maeda,Jun-ichiro Inoue,Kiyoshi Yamaguchi,Koichiro Tsugawa,Makoto Nakanishi,Mariko Morita,Mizuki Yamamoto,Narumi Suzuki,Natsuko Inoue,Reo Maruyama,Satoi Nagasawa,Tomo Osako,Tomohiko Ohta,Wenwen Wu,Yasuo Miyoshi,Yasuyuki Kojima,Yoichi Furukawa,Yoshikazu Johmura

NIH Career Development Awards: conversion to research grants and regional distribution

Marisa L. Conte M. Bishr Omary

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis

Audrey Lafargue,Barry D. Nelkin,Bin Zhang,Brian W. Simons,Dean Felsher,Gokben Yildirir,Hailun Wang,James Verdone,Jennifer Groves,John Wong,Katriana Nugent,Kekoa Taparra,Ken Kang-Hsin Wang,Kenneth J. Pienta,Matthew Ballew,Mustafa A. Barbhuiya,Natasha E. Zachara,Phuoc T. Tran,Reem Malek,Roger Henry,Russell D. Williams,Takumi Shiraishi,Xing Wang

Rare mutations provide unique insight into oncogenic potential of STAT transcription factors

Lisa N. Heppler David A. Frank

NK cells for PD-1/PD-L1 blockade immunotherapy: pinning down the NK cell

Cordelia Dunai William J. Murphy

Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis

Ariel Poliri,Brian Keevil,Hellevi Peltoketo,Ilpo T. Huhtaniemi,Laura Owen,Laura Vengadabady,Luna Samanta,Marcin Chrusciel,Milena Doroszko,Nafis A. Rahman,Olayiwola O. Oduwole

Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

Adrian Gemiarto,Alan G. Baxter,Anton P.J. Middelberg,Bijun Zeng,Davide Moi,Irina Caminschi,Kelli MacDonald,Kirsteen M. Tullett,Meghna Talekar,Mireille H. Lahoud,Ranjeny Thomas,Riccardo Dolcetti,Roberta Mazzieri

The COPII cargo adapter SEC24C is essential for neuronal homeostasis

Alison Krenzer,Amber L. Ward,Bo Wang,Brett J. W. Teubner,David Ginsburg,Elizabeth J. Adams,Joung Hyuck Joo,Mondira Kundu,Rami Khoriaty,Rebecca Mount,Samuel T. Peters,Shondra M. Pruett-Miller,Stanislav S. Zakharenko,Viraj P. Ichhaporia

Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation

Bregina Pool,Christopher J. Hall,Denver Britto,Elina Ashimbayeva,Graham J. Lieschke,Jacquie L. Harper,Jonathan W. Astin,Kathryn E. Crosier,Leslie E. Serson,Lisa M. Lawrence,Maarten van der Kroef,Nicola Dalbeth,Philip S. Crosier

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

Alena Dreiling,Athanasios Stratis,Christiane Geyer,Corinna Wehmeyer,Deblina Chakraborty,Joachim L. Schultze,Johannes Roth,Karin Loser,Mareike Fr？hling,Michael Sch？fers,Monika Stoll,Olympia Papantonopoulou,Peter Paruzel,Selina K. Jorch,Simone K？nig,Stefanie Zenker,Stephan Ludwig,Sumita Thurainayagam,Sven Hermann,Thomas Pap,Thomas Vogl,Tom V？ller,Tomas Leerson,Viktor Wixler

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Alejro Llanos-Chea,Andrew J. Olive,Anneke Lubben,Bailu Xie,Beth A. McCormick,Christina S. Faherty,Christine Tuohy,Christopher Louissaint,Rall J. Mrsny,Rose L. Szabady,Sage E. Foley,Shaun Reeksting,Zachary Demma

Creating a graft-friendly environment for stem cells in diseased brains

Robert Y.L. Tsai

Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

Mira K. Culley Stephen Y. Chan

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

Angela Elizabeth Dean,Collin Heer,David Gius,Douglas R. Spitz,Nobuo Horikoshi,Yueming Zhu

Mitochondrial fidelity and metabolic agility control immune cell fate and function

Michael N. Sack

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

Babal K. Jha,Bartlomiej Przychodzen,Bo T. Porse,Brunangelo Falini,Christian Argueta,Claudiu V. Cotta,David Wald,Francis Enane,Hetty Carraway,Jaroslaw Maciejewski,Maria Paola Martelli,Metis Hasipek,Nicolas Rapin,Quteba Ebrahem,Ramesh Balusu,Reda Z. Mahfouz,Tomas Radivoyevitch,Xiaorong Gu,Yogen Saunthararajah,Yosef Lesman,Zhenbo Hu

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

Alan H. Shih,Allison N. Lau,Amritha Varshini Hanasoge Somasundara,Andrew M. Intlekofer,Anna Sophia McKenney,April Chiu,Barbara Spitzer,Craig B. Thompson,Efthymia Papalexi,Elizaveta Freinkman,Esra A. Akbay,Franck T. Rapaport,Jihae Ahn,Julie Teruya-Feldstein,Kaitlyn Shank,Katharine Yen,Kwok-Kin Wong,Matthew G. Ver Heiden,Minal A. Patel,Mya Steadman,Raajit Rampal,Raj Nagaraja,Ross L. Levine

SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth

Ayako Murao,Hao Zhang,Harriet Kluger,Heejung Kim,Hironari Tamiya,Hyungsoo Kim,Jee Yun Han,Kazuhiro Iwai,Kevin Brown,Lucia Jilaveanu,Oleksiy Klymenko,Scott J. Snipas,Tongwu Zhang,Yongmei Feng,Ze’ev A. Ronai

A common variant alters SCN5A–miR-24 interaction and associates with heart failure mortality

Alaa A. Shalaby,Anne L. Taylor,Arthur M. Feldman,Barry London,Christine S. Moravec,Clyde W. Yancy,Dennis M. McNamara,Douglas R. Spitz,Haider Mehdi,Heather L. Bloom,Jared M. McLendon,Jin-Young Yoon,Kaikobad Irani,Kenneth B. Margulies,Kranti A. Mapuskar,Madhurmeet Singh,Michael Morley,Patrick Breheny,Patrick T. Ellinor,Raul Weiss,Rebecca Gutmann,Ryan L. Boudreau,Samuel C. Dudley,W.H. Wilson Tang,Xiaoming Zhang

HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer

Allison Tyler,Bo Hu,Brian Rini,Caly Chien,Cody J. Peer,Hamid Emamekhoo,Jennifer Taylor,Jorge Garcia,Michael P. Berk,Mohammad Alyamani,Nima Almassi,Nima Sharifi,Petros Grivas,Prateek Mendiratta,Richard J. Auchus,Sunho Park,Sunil Upadhyay,Tae Hyun Hwang,Vadim S. Koshkin,William Douglas Figg

Cell-based molecularly targeted therapy: targeting oncoproteins with T cell receptor gene therapy

Christian S. Hinrichs

Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation

Seung-Yon Lee Fanxin Long

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

Bin Zhang,Dayanira Alsina-Beauchamp,Hisashi Arase,Hong-Ming Hu,Hui-Ming Chen,James A. Duty,Jilu Zhang,Kyeongah Kang,Ping-Ying Pan,Raja Flores,Richard Flavell,Sathish Kumar Mungamuri,Shu-Hsia Chen,Stuart Aaronson,Sunny Mai,Suresh Ramanathan,Thomas Moran,William van der Touw,Yuan Shuo Wang

Bowman’s capsule provides a protective niche for podocytes from cytotoxic CD8+ T cells

Anqun Chen,Chengguo Wei,Detlef Schlondorff,Jia Fu,John Cijiang He,Judith Agudo,Kyung Lee,Tian-Jun Guan,Vivette D. D’Agati

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype

Alexis N. Brumwell,Alfred Li,Chaoqun Wang,David Jablons,Harold A. Chapman,Julie B. Sneddon,Lauren E. Byrnes,Michael A. Matthay,Monica Cassras,Nabora S. Reyes de Mochel,Patty J. Lee,Peiying Shan,Rebecca Moon,Stephanie A. Christenson,Tien Peng,Yasuyuki Yokosaki

Neutralize the neutrophils! Neutrophil β1/β2 integrin activation contributes to JAK2-V617F–driven thrombosis

Stephen T. Oh

Tale of two vaccines: differences in response to herpes zoster vaccines

Anne A. Gershon

Inhibition of neogenin fosters resolution of inflammation and tissue regeneration

Andreas K？rner,Carmen Gerber,Georg Hansmann,Hulda Soffia Jónasdóttir,Martin Giera,Martin Schlegel,Torsten Kaussen,Urs Knausberg,Valbona Mirakaj

Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection

Alexer A. Merleev,Alexra F. Freeman,Alina I. Marusina,Alyssa G. Ashbaugh,Bret L. Pinsker,Carly A. Dillen,Da B. Lee,Emanual Maverakis,Haiyun Liu,Joshua D. Milner,Larissa S. May,Lloyd S. Miller,Loren G. Miller,Mark C. Marchitto,Michael R. Yeaman,Nathan K. Archer,Orly N. Farber,Roger V. Ortines,Scott I. Simon,Shuting S. Cai,Steven K. Lee,Steven M. Holl,Yu Wang

Eya3 promotes breast tumor–associated immune suppression via threonine phosphatase–mediated PD-L1 upregulation

Debashis Ghosh,Heide L. Ford,Hengbo Zhou,James C. Costello,Jared Klarquist,Jill E. Slansky,Lingdi Zhang,Melanie Y. Vincent,Pratyaydipta Rudra,Rani K. Powers,Rebecca L. Vartuli,Ross M. Kedl,Rui Zhao

Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling

Alexra Zanin-Zhorov,Guy Tal,Irun R. Cohen,Liora Cahalon,Ofer Lider,Raanan Margalit

Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons

Mark S. Sonders,Michael Villeneuve,Robin J. Freyberg,Serge Przedborski,Thomas S. Hnasko,Thomas Steinkellner,Vivien Zell,Wei Lu,Zachary Freyberg,Zachary J. Farino

Hepatic Gi signaling regulates whole-body glucose homeostasis

Ama H. Cohen,Hideaki Kaneto,Jie Liu,Jürgen Wess,Lei Wang,Lu Zhu,Mario Rossi,Morris J. Birnbaum,Owen P. McGuinness,Regina J. Lee,Sai Prasad Pydi,Sara M. McMillin,Shanu Jain,Toren Finkel,Travis J. Cyphert,Yanling Ma,Yaron Rotman,Yinghong Cui

PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression

Aditi Mulgaonkar,Guiyang Hao,Haidong Dong,Haidong Tang,Hua Peng,Janis M. Taube,Jian Qiao,Jingya Guo,Kien Nham,Mingyi Chen,Raquibul Hannan,Robert A. Anders,Susan M. Harrington,William Silvers,Xiangyan Qiu,Xiankai Sun,Xin Liu,Yahong Xiong,Yang-Xin Fu,Yangchun Xin,Yong Liang

Zinc transporter Slc39a8 is essential for cardiac ventricular compaction

Daniel J. Rader,Deqiang Li,Feiyan Liu,Jonathan A. Epstein,Lan Cheng,Li Li,Nicholas J. H,Wen Lin

Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits

Bin Li,Chang-Zheng Zhang,Guang-Ying Li,Hong-Zhao Li,Jian-Jun Wang,Jing-Ning Zhu,Kang Xi,Qian-Xing Zhuang,Xiao-Yang Zhang

Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses

Andrew L. Schwaderer,Birong Li,Brian Becknell,Cindy James,Claudia Mosquera,Jackie Metheny,John David Spencer,Kristin Bender,Laura Schwartz,Matthew J. Murtha,Tad Eichler

Seeing the forest for the trees: fractal dimensions measure COPD airway remodeling

Eleanor M. Dunican

Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

Benny Abraham Kaipparettu,Bo Yuan,Dorothy Z. Hu,Feng Li,Frank Sicheri,Haifa Shen,Haoqiang Ying,Jeffrey M. Rosen,Jin Cao,John B. Patterson,Lacey E. Dobrolecki,Leng Han,Longyong Xu,Manisha Talukdar,Michael T. Lewis,Mingzhou Li,Na Zhao,Nagireddy Putluri,Qianzi Tang,Qing Shi,Qingping Zeng,Sean M. Hartig,Wen Bu,Xi Chen,Xia Lin,Xia Liu,Xiangdong Lv,Xiaoran Wang,Xin-Hua Feng,Yang Lu,Yi Jiang,Yingyun Gong,Yiwen Chen,Yu Xiang,Yunfei Wang,Zheng Sun

Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes

Amjad Alkodsi,Govindasamy-Muralidharan Karthik,Gustav St？lhammar,Ikram Ullah,Jens Lagergren,Johan Hartman,John L？vrot,Jonas Bergh,Nelson-Fuentes Martinez,Sampsa Hautaniemi,Una Kj？llquist

COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors

Cristina R. Antonescu,Devan Murphy,Dong Gao,Edward G. Walczak,Elissa W.P. Wong,Gregory Hannon,Inna Sirota,Jenny Q. Zhang,John Wongvipat,Justin Leu,Kenneth Chang,Leili Ran,Ping Chi,Shangqian Wang,Shipra Shukla,Simon R.V. Knott,Wenfu Ma,Youxin Guan,Yu Chen,Yuanyuan Xie,Zhen Cao

Opening windows for bone remodeling through a SLIT

Jameel Iqbal,Mone Zaidi,Se-Min Kim,Tony Yuen

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