Mitochondrial toxicity of organic arsenicals: membrane permeability transition pore opening and respiratory dysfunction

Can Wu,Feng-Lei Jiang,Lian Yuan,Xiao-Yang Fan,Yan-Jun Hu,Yi Liu,Yu-Jiao Liu

Assessing the antiandrogenic properties of propyl paraben using the Hershberger bioassay

Ecem ？zdemir,Mehmet Alper ？etinkaya,Nurhayat Barlas

In silico prediction of chemical genotoxicity using machine learning methods and structural alerts

Defang Fan,Fuxing Li,Guixia Liu,Hongbin Yang,Lixia Sun,Peiwen Di,Weihua Li,Yun Tang

Mechanistic insight into ROS and neutral lipid alteration induced toxicity in the human model with fins (Danio rerio) by industrially synthesized titanium dioxide nanoparticles

Arun Thirumurugan,Biswadeep Das,Ealisha Jha,Hardik Makkar,Mohana Mukherjee,Mrutyunjay Suar,Pritam Kumar Panda,S. K. S. Parashar,Suresh K. Verma

Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner

Bingyan Li,Hong Zhang,Jie Zhang,Lian Xue,Shasha Tao,Zengli Zhang

Outstanding Reviewers for Toxicology Research in 2017

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Craig Rowlands,Thomas Hartung,Thomas Luechtefeld

Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action

Tomoya Yamada

Hemolytic and cellular toxicology of a sulfanilamide-based nonionic surfactant: a niosomal carrier for hydrophobic drugs

Ibrahim Javed,Imdad Ali,Kiramat Shah,Muhammad Raza Shah,Sammer Yousuf,Shakil Ahmed

Delayed death following paraquat poisoning: three case reports and a literature review

Alireza Ebadollahi-Natanzi,Hamid Reza Rahimi,Saeid Ahmadzadeh,Shahin Shadnia,Somayyeh Karami-Mohajeri,Yaghoub Pourshojaei

NF-κB-vimentin is involved in steroidogenesis stimulated by di-n-butyl phthalate in prepubertal female rats

Aihua Gu,Chang Zhang,Lulu Zhang,Minjian Chen,Pan Gong,Shanshan Chen,Yan Ye,Yanhui Hu,Yubang Wang

The mitochondrial pathway is involved in sodium fluoride (NaF)-induced renal apoptosis in mice

Hengmin Cui,Huan Liu,Jing Fang,Junliang Deng,Ling Zhao,Linlin Chen,Qin Luo,Qin Wei,Xun Wang,Yinglun Li,Zhicai Zuo

Genotoxic, histologic, immunohistochemical, morphometric and hormonal effects of di-(2-ethylhexyl)-phthalate (DEHP) on reproductive systems in pre-pubertal male rats

Oxidative stress and mitochondrial impairment mediated apoptotic cell death induced by terpinolene in Schizosaccharomyces pombe

Cemaynur Sarp,Hizlan H. Agus,Meryem Cemiloglu

Molecular insight to size and dose-dependent cellular toxicity exhibited by a green synthesized bioceramic nanohybrid with macrophages for dental applications

Ealisha Jha,Hardik Makkar,Mrutyunjay Suar,Nandini Pramanik,Pritam Kumar Panda,Suresh K. Verma

The developmental toxicity, bioaccumulation and distribution of oxidized single walled carbon nanotubes in Artemia salina

Bin Zhu,Gao-Xue Wang,Jian Li,Song Zhu,Xin Hui

Less toxic zinc(ii), diorganotin(iv), gallium(iii) and cadmium(ii) complexes derived from 2-benzoylpyridine N,N-dimethylthiosemicarbazone: synthesis, crystal structures, cytotoxicity and investigations of mechanisms of action

Jie Li,Ming-Xue Li,Pei-Pei Han,Qiu-Xia Han,Yan Fang

tert-Butylhydroperoxide induces apoptosis in RAW264.7 macrophages via a mitochondria-mediated signaling pathway

Kun Hu,Li-Bo Du,Lu Han,Yan-Chi Sun,Yu-Long Wang,Zi-Yuan Hu

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective

Alan R. Boobis,Ann K. Daly,Daniel J. Antoine,Ian D. Wilson,Jeremy K. Nicholson,Lucia Possamai,Muireann Coen,Toby J. Athersuch

The state of bisphenol research in the lesser developed countries of the EU: a mini-review

Joanna Wojtkiewicz,Liliana Rytel,Michael Thoene,Natalia Nowicka

Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary

Samuel M. Cohen

Collaboration and competition: ethics in toxicology

Emma S. Walker,Ruth A. Roberts

Chromatin dynamics underlying latent responses to xenobiotics

The safety evaluation of food flavouring substances: the role of metabolic studies

Christie L. Harman,F. Peter Guengerich,Ivonne M. C. M. Rietjens,Margaret M. McGowen,Maria Bastaki,Nigel J. Gooderham,Robert L. Smith,Samuel M. Cohen,Sean V. Taylor,Shoji Fukushima,Stephen S. Hecht

Risk assessment of inhalation exposure to VOCs in dwellings in Chongqing, China

Baizhan Li,Han Wang,Jie Xiong,Tujingwa Zhang,Wei Yu,Zhongming Bu,Zhu Cheng

Systematic toxicity investigation of graphene oxide: evaluation of assay selection, cell type, exposure period and flake size

S. Zou,V. Gies

The hypothalamic–pituitary–testicular axis and the testicular function are modulated after silver nanoparticle exposure

C. A. Oliveira,I. M. Oliveira,M. A. Romano,M. D. Cavallin,N. C. S. Cardoso,N. M. Khalil,R. M. Romano,R. Wilk

Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport in vivo

Dai Cheng,Jiankang Cao,Weibo Jiang,Xiaomei Wang,Yu Xi

In vitro effects of endosulfan-based insecticides on mammalian sperm

C. Alvarez Sedó,F. Lo Nostro,G. R. Chaufan,J. C. Calvo,M. C. Sánchez,M. Romanato,R. Da Cu？a,V. Fontana

Changes in silica nanoparticles upon internalisation by cells: size, aggregation/agglomeration state, mass- and number-based concentrations

Christian Gollwitzer,Dorota Bartczak,Heidi Goenaga-Infante,Julie Davies,Michael Krumrey

Arsenic trioxide exposure accelerates colon preneoplasic aberrant crypt foci induction regionally through mitochondrial dysfunction

Bahia Djerdjouri,Belkacem Mohamed Amine Boumaza,Hichem Moulahoum,Meriem Ferrat

The systemic toxicity of heavy metal mixtures in rats

Hong Su,Jinshun Zhao,Joni Aldinger,Lu Kong,Min Ding,Qihang Hua,Samuel Selorm Fiati Kenston,Tabatha Barber,Xialu Lin,Xin Song,Yafei Wang,Yuanliang Gu,Zhen Li,Zhou Li

Upregulated has-miR-4516 as a potential biomarker for early diagnosis of dust-induced pulmonary fibrosis in patients with pneumoconiosis

Jianan Hu,Ruixue Huang,Ting Yu,Ying Li

In silico identification of protein targets for chemical neurotoxins using ToxCast in vitro data and read-across within the QSAR toolbox

H. A. Pangburn,H. W. Shows,J. M. Gearhart,Y. G. Chushak

Evaluation of the toxic potential of arecoline toward the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9

Barkha Shakya,Yasir Hasan Siddique

Pharmacognostic and pharmacological evaluation of Eulaliopsis binata plant extracts by measuring in vitro/in vivo safety profile and anti-microbial potential

Arun K. Sharma,Mahesh Pal,Neerupma Dhiman,Satyendra K. Rajput,Vinod Kumar

Neurochemical characterization of nerve fibers in the porcine gallbladder wall under physiological conditions and after the administration of Salmonella enteritidis lipopolysaccharides (LPS)

Anita Mikolajczyk,Jaroslaw Calka,Krystyna Makowska,Slawomir Gonkowski

Bifenthrin-induced neurotoxicity in rats: involvement of oxidative stress

Farah Syed,Inderpal Soni,Kumud K. Awasthi,Lalit P. Chandravanshi,Neelu K. Rajawat,P. J. John,Rajbala Verma,Vinay K. Khanna

The effect of bisphenol A on testicular steroidogenesis and its amelioration by quercetin: an in vivo and in silico approach

Chirag N. Patel,Hetal Doctor,Himanshu A. Pandya,R. J. Verma,Sanman Samova

Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

Alan Poole,David A. Basketter,Ian Kimber

Perturbation of microRNA signalling by doxorubicin in spermatogonial, Leydig and Sertoli cell lines in vitro

Emma L. Marczylo,Oluwajoba O. Akinjo,Timothy W. Gant

The failure of rodent carcinogenesis as a model for Man

Colin Berry

Goodbye to the bioassay

Jay I. Goodman

The subchronic exposure to malathion, an organophosphate pesticide, causes lipid peroxidation, oxidative stress, and tissue damage in rats: the protective role of resveratrol

Damla Arslan-Acaroz,Erten Akbel,Hasan Huseyin Demirel,Ismail Kucukkurt,Sinan Ince

Cytometrical analysis of the adverse effects of indican, indoxyl, indigo, and indirubin on rat thymic lymphocytes

Ayako Azuma,Kaori Kanemaru,Mizuki Ishikawa,Satoru Itsuki,Shogo Hirai,Yasuaki Tamura,Yasuo Oyama,Yurie Funakoshi

Amino-PAHs activated Nrf2/ARE anti-oxidative defense system and promoted inflammatory responses: the regulation of PI3K/Akt pathway

Jing An,Meiying Wu,Mingyuan Liu,Yu Shang,Yuting Jiang

Are metals and pyrene levels additional factors playing a pivotal role in air pollution-induced inflammation in taxi drivers?

Adriana Gioda,Anelise Barth,Bruna Gauer,Flávia V. Thiesen,Jessica Nardi,Marcelo D. Arbo,Natália Brucker,Solange C. Garcia

Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs

Jianhua Qin,Lei Jiang,Li Wang,Lijian Hui,Wentao Su,Yang Liu,Yaqing Wang

The interactions of CdTe quantum dots with serum albumin and subsequent cytotoxicity: the influence of homologous ligands

Bing-Qiong Yu,Feng-Lei Jiang,Miao-Miao Yin,Ren Yan,Xiao-Le Han,Xun Xiang,Yi Liu,Zhi-Qiang Zhou

Genotoxicity inhibition by Syzygium cumini (L.) seed fraction and rutin: understanding the underlying mechanism of DNA protection

Afzal Hussain,Faizan Abul Qais,Iqbal Ahmad,Mohamed F. Alajmi,Mohammad Shavez Khan