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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 2059-3635

ISSN Online:

主页: https://www.nature.com/sigtrans

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Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning

Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy

Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 in Pneumocystis carinii

Targeting growth hormone function: strategies and therapeutic applications

Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy

Signal-induced PARP1-Erk synergism mediates IEG expression

Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma

Pazopanib in advanced soft tissue sarcomas

Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer

The roles of prostaglandin F2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes

The role of autophagy in colitis-associated colorectal cancer

Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases

ETV2 mediates endothelial transdifferentiation of glioblastoma

Controlled drug delivery vehicles for cancer treatment and their performance

DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells

Targeting oncogenic Myc as a strategy for cancer treatment

The intracellular signalosome of PD-L1 in cancer cells

USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia

Metabolite sensing and signaling in cell metabolism

TdIF1: a putative oncogene in NSCLC tumor progression

Context-dependent AMPK activation distinctly regulates TAp73 stability and transcriptional activity

RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells

The independence of and associations among apoptosis, autophagy, and necrosis

Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer

miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition

Targeted chemotherapy for subcutaneous and orthotopic non-small cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin

Loss of mdig expression enhances DNA and histone methylation and metastasis of aggressive breast cancer

γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential

Counterbalance: modulation of VEGF/VEGFR activities by TNFSF15

Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma

The dual-inhibitory effect of miR-338-5p on the multidrug resistance and cell growth of hepatocellular carcinoma

Targeting IL-2: an unexpected effect in treating immunological diseases

Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models

miRNAs reshape immunity and inflammatory responses in bacterial infection

Detection of PRMT1 inhibitors with stopped flow fluorescence

Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer

Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer

A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer

Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival

Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy, and tumor-targeting S. typhimurium A1-R is superior to first-line chemotherapy

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