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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 2056-7189

ISSN Online:

主页: https://www.nature.com/npjsba

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The multiplex network of human diseases

Ranking network mechanisms by how they fit diverse experiments and deciding on E. coli's ammonium transport and assimilation network

Identification of an early cell fate regulator by detecting dynamics in transcriptional heterogeneity and co-regulation during astrocyte differentiation

Parsimonious Gene Correlation Network Analysis (PGCNA): a tool to define modular gene co-expression for refined molecular stratification in cancer

Novel insights into gene expression regulation during meiosis revealed by translation elongation dynamics

Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models

Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes

PIMKL: Pathway-Induced Multiple Kernel Learning

A yield-cost tradeoff governs Escherichia coli’s decision between fermentation and respiration in carbon-limited growth

An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration

Mathematical modeling of diurnal patterns of carbon allocation to shoot and root in Arabidopsis thaliana

Defining rules for cancer cell proliferation in TRAIL stimulation

Handling variability and incompleteness of biological data by flexible nets: a case study for Wilson disease

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types

Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation

Mapping the operational landscape of microRNAs in synthetic gene circuits

ComPath: an ecosystem for exploring, analyzing, and curating mappings across pathway databases

Multi-experiment nonlinear mixed effect modeling of single-cell translation kinetics after transfection

Mathematical model of hemodynamic mechanisms and consequences of glomerular hypertension in diabetic mice

Context-dependent prediction of protein complexes by SiComPre

A landscape view on the interplay between EMT and cancer metastasis

Redefining environmental exposure for disease etiology

Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations

Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes

A machine learning approach to predict metabolic pathway dynamics from time-series multiomics data

Detecting phenotype-driven transitions in regulatory network structure

Large-scale computational drug repositioning to find treatments for rare diseases

Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer

Pathway crosstalk enables cells to interpret TGF-β duration

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Transcriptional timing and noise of yeast cell cycle regulators—a single cell and single molecule approach

A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis

Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms

Mapping biological process relationships and disease perturbations within a pathway network

A network of epigenomic and transcriptional cooperation encompassing an epigenomic master regulator in cancer

From metagenomic data to personalized in silico microbiotas: predicting dietary supplements for Crohn’s disease

Modeling gene-regulatory networks to describe cell fate transitions and predict master regulators

Regeneration in distantly related species: common strategies and pathways

Stochastic system identification without an a priori chosen kinetic model—exploring feasible cell regulation with piecewise linear functions

A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection

A roadmap towards personalized immunology

Regulatory feedback response mechanisms to phosphate starvation in rice

Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability

Role of noise and parametric variation in the dynamics of gene regulatory circuits

The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches

Prevalence and patterns of higher-order drug interactions in Escherichia coli

Flux-dependent graphs for metabolic networks

©2008-2020 OALib, Inc | Public user content licensed CC-BY 4.0 unless otherwise specified. OALib ISSN Online: 2333-9721 OALib ISSN Print: 2333-9705