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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 2056-5968

ISSN Online:

主页: https://www.nature.com/celldisc

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Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses

Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13

The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system

Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency

A chemical approach for global protein knockdown from mice to non-human primates

Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses

Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome

Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling

USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia

Regrowth-delay body as a bacterial subcellular structure marking multidrug-tolerant persisters

Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

Targeting JNK pathway promotes human hematopoietic stem cell expansion

SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists

Optimizing genome editing strategy by primer-extension-mediated sequencing

DNA methylation reprogramming of functional elements during mammalian embryonic development

Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation

Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase

Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance

Postsynaptic p47phox regulates long-term depression in the hippocampus

Response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA

Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity

Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869

abLIM1 constructs non-erythroid cortical actin networks to prevent mechanical tension-induced blebbing

Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging

Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle

CARK1 mediates ABA signaling by phosphorylation of ABA receptors

Structural visualization of RNA polymerase III transcription machineries

Merge and separation of NuA4 and SWR1 complexes control cell fate plasticity in Candida albicans

Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release

HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function

Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure

SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements

Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9

Repurposing CRISPR-Cas12b for mammalian genome engineering

ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification

Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice

RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases

Sequence determinants of specific pattern-recognition of bacterial ligands by the NAIP–NLRC4 inflammasome

Four putative SWI2/SNF2 chromatin remodelers have dual roles in regulating DNA methylation in Arabidopsis

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis

A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance

Genetic editing and interrogation with Cpf1 and caged truncated pre-tRNA-like crRNA in mammalian cells

A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating

Maintenance of human haematopoietic stem and progenitor cells in vitro using a chemical cocktail

Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription

©2008-2020 OALib, Inc | Public user content licensed CC-BY 4.0 unless otherwise specified. OALib ISSN Online: 2333-9721 OALib ISSN Print: 2333-9705