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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 1476-5403

ISSN Online:

主页: https://www.nature.com/cdd

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Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease

Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation

The KRAS-variant and its impact on normal breast epithelial cell biology

MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells

Liver stage malaria infection is controlled by host regulators of lipid peroxidation

UBAP2L arginine methylation by PRMT1 modulates stress granule assembly

MEST induces Twist-1-mediated EMT through STAT3 activation in breast cancers

Bok regulates mitochondrial fusion and morphology

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

Ly6G+ inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model

Sam50–Mic19–Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact

MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways

TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy

Transcription factor TEAD1 is essential for vascular development by promoting vascular smooth muscle differentiation

ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks

Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury

Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

CHK1 dosage in germinal center B cells controls humoral immunity

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail

Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts constitutes the hepatocarcinogenesis-associated microenvironment

Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery

TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons

CBP and SRF co-regulate dendritic growth and synaptic maturation

PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection

TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2

STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex

Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways

JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1

Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells

Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma

Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

©2008-2020 OALib, Inc | Public user content licensed CC-BY 4.0 unless otherwise specified. OALib ISSN Online: 2333-9721 OALib ISSN Print: 2333-9705