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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 1552-4469

ISSN Online:

主页: https://www.nature.com/nchembio

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Structure of McsB, a protein kinase for regulated arginine phosphorylation

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor

Natural fumigation as a mechanism for volatile transport between flower organs

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

Small-molecule control of antibody N-glycosylation in engineered mammalian cells

MCC950 closes the active conformation of NLRP3 to an inactive state

Structural and mechanistic basis of mammalian Nudt12 RNA deNADding

Rewiring bacterial two-component systems by modular DNA-binding domain swapping

Light-based control of metabolic flux through assembly of synthetic organelles

Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules

Optical control of sphingosine-1-phosphate formation and function

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals

Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale

An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

Dual phenazine gene clusters enable diversification during biosynthesis

Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision

Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation

Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair

Metalloprotein switches that display chemical-dependent electron transfer in cells

Affinity-based capture and identification of protein effectors of the growth regulator ppGpp

Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

Design of fast proteolysis-based signaling and logic circuits in mammalian cells

Structural basis of 7SK RNA 5′-γ-phosphate methylation and retention by MePCE

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Polarized displacement by transcription activator-like effectors for regulatory circuits

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

Identification of a cellularly active SIRT6 allosteric activator

Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking

Small-molecule-based regulation of RNA-delivered circuits in mammalian cells

The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite

A DNA-based fluorescent reporter maps HOCl production in the maturing phagosome

Acetylation of intrinsically disordered regions regulates phase separation

Structural basis for ligand recognition of the human thromboxane A2 receptor

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis

Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability

Activation of silent biosynthetic gene clusters using transcription factor decoys

Riboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function

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