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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 1476-4679

ISSN Online:

主页: https://www.nature.com/ncb

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U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

EGFR is required for Wnt9a–Fzd9b signalling specificity in haematopoietic stem cells

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation

Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency

Cellular functions of long noncoding RNAs

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

A lipid-based partitioning mechanism for selective incorporation of proteins into membranes of HIV particles

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

An opsin 5–dopamine pathway mediates light-dependent vascular development in the eye

A nuclear phosphoinositide kinase complex regulates p53

Apical–basal polarity inhibits epithelial–mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

A complex containing lysine-acetylated actin inhibits the formin INF2

Ultrastructure and dynamics of the actin？myosin II cytoskeleton during mitochondrial fission

A microRNA-inducible CRISPR–Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool

Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification

RNA modifications regulating cell fate in cancer

The RNA N6-methyladenosine modification landscape of human fetal tissues

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response

AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression

53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes

Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation

Dormant tumour cells, their niches and the influence of immunity

N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation

A chromatin integration labelling method enables epigenomic profiling with lower input

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

Life, death and autophagy

TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling

Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities

The challenge of the post-truth era

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Multiple phosphorylations control recruitment of the KMN network onto kinetochores

CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis

The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria

Direct induction of microtubule branching by microtubule nucleation factor SSNA1

CRISPR–Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development

Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin

Autophagy and the cell biology of age-related disease

Single particle trajectories reveal active endoplasmic reticulum luminal flow

©2008-2020 OALib, Inc | Public user content licensed CC-BY 4.0 unless otherwise specified. OALib ISSN Online: 2333-9721 OALib ISSN Print: 2333-9705