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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 1546-170X

ISSN Online:

主页: https://www.nature.com/nm

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Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial

A safe and potent anti-CD19 CAR T cell therapy

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

The pros, cons, and many unknowns of probiotics

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

The landscape of cancer cell line metabolism

End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography

Rational design of anti-GITR-based combination immunotherapy

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Methionine is a metabolic dependency of tumor-initiating cells

Human 3D cellular model of hypoxic brain injury of prematurity

IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

The molecular landscape of glioma in patients with Neurofibromatosis 1

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Diversifying clinical trials

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

The emerging link between cancer, metabolism, and circadian rhythms

RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer

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