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OALib Journal期刊
ISSN: 2333-9721
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants

The Direct Molecular Target for Imipridone ONC201 Is Finally Established

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways

CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

The Origin of CIMP, At Last

Waun Ki Hong (1942–2019) John Mendelsohn (1936–2019)

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis

The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Teaching an Old Drug New Tricks

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors

A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis

Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors

Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

UTX Mutations in Human Cancer

Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

“Breathing” Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns

Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

Star Power: Astrocytes Regulate Behavior

The Coming Decade of Cell Death Research: Five Riddles

Flu Shows the Power of Diversity

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

Lung Cancer Evolution: What’s Immunity Got to Do with It?

Drowning in Viruses

Sydney Brenner (1927–2019)

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Marine DNA Viral Macro- and Microdiversity from Pole to Pole

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

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©2008-2020 OALib, Inc | Public user content licensed CC-BY 4.0 unless otherwise specified. OALib ISSN Online: 2333-9721 OALib ISSN Print: 2333-9705