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OALib Journal期刊
ISSN: 2333-9721
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Human Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro

Dimiter S. Dimitrov,Hongqian Wang,Wei Li,Weizao Chen,Yanping Wang,Zuoxiang Xiao

IgG Charge: Practical and Biological Implications

Danlin Yang,Rachel Kroe-Barrett,Sanjaya Singh,Thomas Laue

David vs. Goliath: The Structure, Function, and Clinical Prospects of Antibody Fragments

Adam Bates,Christine A. Power

Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases

Danica Stanimirovic,Jamshid Tanha,Kasandra Bélanger,Maria Moreno,Roger MacKenzie,Umar Iqbal

Kinetic Analysis and Epitope Mapping of Monoclonal Antibodies to Salmonella Typhimurium Flagellin Using a Surface Plasmon Resonance Biosensor

Devendra Bhandari,Fur-Chi Chen,Roger C. Bridgman,Shreya Hamal

The Ligands for Human IgG and Their Effector Functions

Gestur Vidarsson,Steven W. de Taeye,Theo Rispens

Binding of Immunoglobulin G to Protoporphyrin IX and Its Derivatives: Evidence the Fab Domain Recognizes the Protoporphyrin Ring

Koichi Orino

A Strategy to Optimize the Generation of Stable Chromobody Cell Lines for Visualization and Quantification of Endogenous Proteins in Living Cells

Bettina-Maria Keller,Bjoern Traenkle,Julia Maier,Melissa Weldle,Soeren Segan,Ulrich Rothbauer

Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276, an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody against HER-2

Anton I. Rosenbaum,Brandon Lam,Eric Ma,Marlking Peay,Meina Liang,Michael Waldron,Morse Faria,Moucun Yuan,William R. Mylott, Jr.

Using Nanobodies to Study Protein Function in Developing Organisms

Gustavo Aguilar,M. Alessandra Vigano,Markus Affolter,Shinya Matsuda

Single-Domain Antibodies and Their Formatting to Combat Viral Infections

Bert Schepens,Dorien De Vlieger,Iebe Rossey,Marlies Ballegeer,Xavier Saelens

The Diagnostic and Clinical Utility of Autoantibodies in Systemic Vasculitis

Elena Csernok

Preferential Identification of Agonistic OX40 Antibodies by Using Cell Lysate to Pan Natively Paired, Humanized Mouse-Derived Yeast Surface Display Libraries

Adam S. Adler,Angélica V. Medina-Cucurella,Ariel R. Niedecken,Ayla Nelson,David S. Johnson,Jackson Leong,Jan Fredrik Simons,Kacy Stadtmiller,Matthew J. Spindler,Michael A. Asensio,Nicholas Wayham,Rena A. Mizrahi,Renee Leong,Robert C. Edgar,Yoong Wearn Lim

Immunogenicity of Innovative and Biosimilar Monoclonal Antibodies

Erik Doevendans,Huub Schellekens

Targeting the MHC Ligandome by Use of TCR-Like Antibodies

Geir ？ge L？set,Inger Sandlie,Lene St？kken H？ydahl,Rahel Frick

Peptides for Infectious Diseases: From Probe Design to Diagnostic Microarrays

Alessandro Gori,Giorgio Colombo,Ilda D’Annessa,Marcella Chiari,Marina Cretich

Evaluation of the NovaLisa？ Leishmania Infantum IgG ELISA in A Reference Diagnostic Laboratory in A Non-Endemic Country

Amalie Vang H？st,Christen Rune Stensvold,Henrik Vedel Nielsen,Salem Belkessa

Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin

Christina Ball,Chung Y. Cheung,George W. Carnell,Nigel Temperton,Othmar G. Engelhardt,Paul Risley,Simon E. Hufton,Tiziano Gaiotto,Walter Ramage

Macro- and Micro-Heterogeneity of Natural and Recombinant IgG Antibodies

Alain Beck,Hongcheng Liu

Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning

Christopher B. Howard,Christopher J. de Bakker,Linda Harkness,Martina L. Jones,Michael Yeh,Mohamed A. Alfaleh,Neetika Arora,Philip Macpherson,Rachel E. Allavena,Stephen M. Mahler,Xiaoli Chen

Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation

Aline Zimmer,Harald Kolmar,Janike Ehret,Martina Zimmermann

Targeted Nanobody-Based Molecular Tracers for Nuclear Imaging and Image-Guided Surgery

Nick Devoogdt,Pieterjan Debie,Sophie Hernot

Selection and Characterization of a Nanobody Biosensor of GTP-Bound RHO Activities

Aurélien Olichon,Claudine Tardy,Gilles Favre,Laetitia Ligat,Laura Keller,Nicolas Bery,Terence H. Rabbitts

Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer

Patrick Chames,Timothée Chanier

A RAGE-Targeted Antibody-Drug Conjugate: Surface Plasmon Resonance as a Platform for Accelerating Effective ADC Design and Development

Asa Frostell,Deyarina Gonzalez,Gareth D. Healey,R. Steven Conlan,Tim Fagge

Pharmacologic Considerations in the Disposition of Antibodies and Antibody-Drug Conjugates in Preclinical Models and in Patients

Allison N. Schorzman,Andrew T. Lucas,Joseph A. Piscitelli,Juan F. Razo,Ryan Robinson,William C. Zamboni

Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy

Bj？rn Rissiek,Carolina Pinto-Espinoza,Friedrich Koch-Nolte,Larissa Jank,Tim Magnus,Yinghui Duan

Computational Prediction of the Epitopes of HA1 Protein of Influenza Viruses to its Neutralizing Antibodies

Chao Huang,Fiona S. Legge,Herbert R. Treutlein,Jun Zeng,Xiao Zhang,Xiaoyan Zeng,Yongjun Jiao

IgE Antibodies: From Structure to Function and Clinical Translation

Anna M. Davies,Brian J. Sutton,Heather J. Bax,Sophia N. Karagiannis

VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells

Hans de Haard,Mercedes Ramirez-Escudero,Paul. M.P. van Bergen en Henegouwen,Raimond Heukers,Sabrina Oliveira,Theo C. Verrips,Vida Mashayekhi

IMGT？ and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function

Gérard Lefranc,Marie-Paule Lefranc

Small-Format Drug Conjugates: A Viable Alternative to ADCs for Solid Tumours?

Anja Pomowski,Ashleigh C. Stewart,Bryan M. Edwards,Gokhan Yahioglu,Ioanna Stamati,James Clarke,Mahendra P. Deonarain,Soraya Diez-Posada

Evaluation of Continuous Membrane Chromatography Concepts with an Enhanced Process Simulation Approach

Dominik Stein,Jochen Strube,Steffen Zobel-Roos

Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display

Chuan Chen,Haiying Hang,Jie Wang,Long Chen,Shaopeng Chen,Yun Zhao,Zhishang Hu

Factors Affecting the Pharmacology of Antibody–Drug Conjugates

Allison N. Schorzman,Andrew T. Lucas,Joseph A. Piscitelli,Juan Razo,Lauren S. L. Price,Mallory Storrie,William C. Zamboni

OptMAVEn-2.0: De novo Design of Variable Antibody Regions against Targeted Antigen Epitopes

Costas D. Maranas,Matthew F. Allan,Ratul Chowdhury

Relative Contribution of Framework and CDR Regions in Antibody Variable Domains to Multimerisation of Fv- and scFv-Containing Bispecific Antibodies

David P. Humphreys,Pallavi Bhatta

Molecular Recognition between Aβ-Specific Single-Domain Antibody and Aβ Misfolded Aggregates

Buyong Ma,Jie Zheng,Mingzhen Zhang,Ruth Nussinov

Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

David Rabuka,Dominick Yeo,Jesse McFarland,Qiuting Hong,Robyn M. Barfield,Thomas Linz,Wesley Zmolek,William E. Haskins

Selection of Single-Domain Antibodies towards Western Equine Encephalitis Virus

Dan Zabetakis,Ellen R. Goldman,George P. Anderson,Jinny L. Liu,Lisa C. Shriver-Lake

Myelin Antigens and Antimyelin Antibodies

Fredrick J. Seil

Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds

Dana Litvak-Greenfeld,Galia Matatov,Iris Alroy,Itai Benhar,LeeRon Shefet-Carasso,Lilach Vaks,Limor Nahary,Rahely Hakim,Shiran Shapira,Stav Dror

Thinking outside the Laboratory: Analyses of Antibody Structure and Dynamics within Different Solvent Environments in Molecular Dynamics (MD) Simulations

Karina Kubiak-Ossowska,Mohammed M. Al Qaraghuli,Paul A. Mulheran

Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility

Anja Vilkman,Annamari Heiskanen,Bram Herpers,Henna Pynn？nen,Jari Helin,Juhani Saarinen,Leo S. Price,Tero Satomaa,Titta Kotiranta,Virve Pitk？nen

ADME Considerations and Bioanalytical Strategies for Pharmacokinetic Assessments of Antibody-Drug Conjugates

Anton I. Rosenbaum,Si Mou,Yue Huang

Genetic Fusion of an Anti-BclA Single-Domain Antibody with Beta Galactosidase

Dan Zabetakis,Ellen R. Goldman,George P. Anderson,Jinny L. Liu,Joyce C. Breger,Lauryn Ashford,Lisa C. Shriver-Lake,P. Audrey Brozozog Lee,Scott A. Walper

Tuning Relative Polypeptide Expression to Optimize Assembly, Yield and Downstream Processing of Bispecific Antibodies

Elise Fleury,Florence Gauye,Giovanni Magistrelli,Guillemette Pontini,Jérémie Bourguignon,Lydia Galissaires,Nicolas Fischer,Nicolas Plèche,Pauline Malinge,Yves Poitevin

BPSL1626: Reverse and Structural Vaccinology Reveal a Novel Candidate for Vaccine Design against Burkholderia pseudomallei

Arnone Nithichanon,Claudio Peri,Daniel Yero,Ganjana Lertmemongkolchai,Giorgio Colombo,Louise J. Gourlay,Marcella Chiari,Marina Cretich,Martino Bolognesi,Oscar Conchillo-Solé,Paola Gagni,Riccardo Capelli,Riccardo Villa,Xavier Daura

Tumor-Directed Blockade of CD47 with Bispecific Antibodies Induces Adaptive Antitumor Immunity

Elie Dheilly,Gérard Didelot,Krzysztof Masternak,Laurence Chatel,Lucile Broyer,Marie H. Kosco-Vilbois,Nicolas Fischer,Pauline Malinge,Stefano Majocchi,Sébastien Calloud,Valéry Moine,Walter G. Ferlin

A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates

Brian M. G. Janssen,Floris L. Van Delft,Jorge M. M. Verkade,Marloes A. Wijdeven,Remon Van Geel,Sander S. Van Berkel

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