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ISSN: 2333-9721
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Theranostics

ISSN Print: 1838-7640

ISSN Online:

主页: http://www.thno.org

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Platelet-camouflaged nanococktail: Simultaneous inhibition of drug-resistant tumor growth and metastasis via a cancer cells and tumor vasculature dual-targeting strategy

Chaojian Zhu,Dongqi Wu,Haijing Qu,Jian Zheng,Lijia Jing,Xiangsheng Shi,Xing Jin,Xiufeng Yan,Yang Wang,Yongbo Yang

Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma

Botai Li,Chen Yang,Chengtao Yu,Fangyu Zhao,Haojie Jin,Hui Wang,Jia He,Jinjun Li,Lin Huan,Lin Wei,Linhui Liang,Lunxiu Qin,Ming Yao,Qiongzhu Dong,Wenxin Qin,Xianghuo He

Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system

Liping Tang,Samuel Achilefu,Siwen Li,Yalan Rui,Yueqing Gu,Yuxi Liu

Long non-coding RNAs AC026904.1 and UCA1: a “one-two punch” for TGF-β-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer

An-Gang Yang,Bo Xin,Dai-Ming Fan,Guo-Yin Li,Hua Han,Jian-Yong Sun,Lei Wang,Li-Bo Yao,Lin-Tao Jia,Qian-Feng Zhang,Ting Wang,Wei Wang,Xiang Zhang

MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3

Aishan He,Dianbo Long,Fangang Meng,Minghui Gu,Peihui Wu,Shu Hu,Suiwen He,Weiming Liao,Xiaoyi Zhao,Yan Kang,Zhiqi Zhang,Zhiwen Li,Zibo Yang,Zongkun Chang

Catalytic hairpin assembly gel assay for multiple and sensitive microRNA detection

Dongdong Wang,Haifeng Dong,Jie He,Jing Zhang,Kai Zhang,Wenhao Dai,Xiangdan Meng,Xueji Zhang,Yu Cao

In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation

Amanda J Kiliaan,Andreas H Jacobs,Bastian Zinnhardt,Cristina Barca,Lisa Honold,Maximilian Wiesmann,Michael Sch？fers

The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction

Bryan Holvoet,Catherine M. Verfaillie,Christophe M. Deroose,Esther Wolfs,Hubert Vanbilloen,Ivo Lambrichts,Katrien Neyrinck,Maurilio Sampaolesi,Natacha Breuls,Olivier Gheysens,Robin Duelen,Uwe Himmelreich,Willy Gsell,Wouter Oosterlinck

Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer

Alexander L. Klibanov,Anne M. Mills,Galina Diakova,Jill K. Slack-Davis,Kimberly A. Kelly,Michael F. Gutknecht,Ryo Suzuki,Siva Sai Krishna Dasa

Molecular Detection and Analysis of Exosomes Using Surface-Enhanced Raman Scattering Gold Nanorods and a Miniaturized Device

Elizabeth R. Butch,Elyahb Allie Kwizera,Melody Williams,Ryan O'Connor,Scott E. Snyder,Vojtech Vinduska,Xiang Chen,Xiaohua Huang

Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer

Hanjun Hao,Jianwen Guo,Kun Wang,Mengmeng Sun,Tong Tong,Weiping Gao

G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1

Jian Ding,Jie Zhang,Pengxing He,Yafang Wang,Yanyan Shen,Yi Chen

Polypyrrole-chitosan conductive biomaterial synchronizes cardiomyocyte contraction and improves myocardial electrical impulse propagation

Guo-Qing Du,Hsing-Wen Sung,Jun Wu,Nathan C. Ni,Ren-Ke Li,Richard D. Weisel,Sheng He,Terrence M. Yau,Zhi Cui

Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics

Christopher Lyon,Jia Fan,Meihua Wan,Meryl Rodrigues,Ye Hu

Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery

Bohan Ma,Chun Yin,Hao Guo,Jin Yan,Kaishan Tao,Min Liu,Peng Hou,Simeng Wang,Wangxiao He,Yi Guo,Yi Zhou,Yijie Li,Zhenyuan Bian,Zhijie Lei

Development of an Accurate and Proactive Immunomodulatory Strategy to Improve Bone Substitute Material-Mediated Osteogenesis and Angiogenesis

Ding-yu Wu,Jian Sun,Jin-bing Wang,Ming-ming Lv,Xian-song Wang,Ya-hong Chen,Zhi-Yong Zhang,Zhi-wei Zheng

Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model

Bo Hai,Chunmei Zhang,Fei Liu,Jingsong Wang,Liang Hu,Linsha Ma,Lizheng Qin,Qingguo Zhao,Shimin Chang,Songlin Wang,Xiangchun Li,Xiaoshan Wu,Xiaoyu Feng,Yipu Xu,Zhao Zhu

Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism

Amit Gupta,Austin Yeon,Daniel J. Weisenberger,Gangning Liang,Jayoung Kim,Minhyung Kim,Myung Hee Park,Sungyong You

State-of-the-art of microbubble-assisted blood-brain barrier disruption

Brandon K. Harvey,Kang-Ho Song,Mark A. Borden

Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy

Chan Yang,Ge-Zhi Kong,Hong-Min Meng,Ting Fu,Xiao-Bing Zhang,Xiao-Xiao Hu,Zhao-Hui Li

Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1

Dae Hwan Shin,Dong Ju Son,Jae-Kyung Jung,Jaesuk Yun,Jeong Soon Choi,Ji Young Kim,Jin Tae Hong,Ju Kyung Song,Ki Cheon Kim,Sang-Bae Han,Sin Kook Kang,Sun Young Kim,Yoon-Seok Roh,Yu Ri Kim

Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer

Cho Low,Dong Kong,Fuming Qiu,Jian Huang,Jun Wu,Jun Ye,Pu Cheng,Qi Huang,Shenghang Jin,Wenlu Li,Wenteng Chen,Xinchi Yi,Yikun Guo,Yongpin Yu,YueHua Han,Zhigang Chen,Zhou Jiang

Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness

Ashley M. Mohr,Cody J. Wehrkamp,David Oupicky？,Geoffrey A. Talmon,Jing Li,Justin L. Mott,Lee Jaramillo,Mary Anne Phillippi,Yazhe Wang,Yi Chen,Ying Xie,Yu Hang

Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

Chen Zhao,Huiping Sun,Jian-Qing Mi,Jiang Zhu,Jie Xu,Junmei Zhao,Junmin Li,Pier Paolo Pandolfi,Qiusheng Chen,Saijuan Chen,Wu Zhang,Xiangqin Weng,Xiaojing Yan,Yongmei Zhu,Zhu Chen

Recommendations for reporting on emerging optical imaging agents to promote clinical approval

Alexander L. Vahrmeijer,Eben L. Rosenthal,Jason M Warram,Nynke S. van den Berg,Rutger-Jan Swijnenburg,Sarah E. Miller,Willemieke S. Tummers

Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development

Hong Nam Kim,Hyung-Jun Koo,Jonghoon Choi,Kyobum Kim,Nakwon Choi,Yeonho Jo

Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer

Biliang Chen,Fuxing Zhou,Hang Zhao,Jia Li,Rui An,Xiaohui Lv,Xiaoshan Yang,Yang Feng,Yu Liu

EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers

Chen Xie,Ga-Lai Law,Hong Lok Lung,Ka-Leung Wong,Kwok Wai Lo,Lijun Jiang,Nai-Ki Mak

Self-assembly of porphyrin-grafted lipid into nanoparticles encapsulating doxorubicin for synergistic chemo-photodynamic therapy and fluorescence imaging

Min Chen,Nisi Zhang,Pravin Bhattarai,Sadaf Hameed,Xiaolong Liang,Yunxue Xu,Zhifei Dai

Increasing lean muscle mass in mice via nanoparticle-mediated hepatic delivery of follistatin mRNA

Abraham S. Moses,Adam W. G. Alani,Anna St. Lorenz,Canan Schumann,Daniel L. Marks,Duc X. Nguyen,Hassan A. Albarqi,Katherine Michaelis,Leon Wong,Mason Norgard,Oleh Taratula,Olena R. Taratula,Stephanie Chan,Stephanie Krasnow,Tetiana Korzun,Xinxia Zhu,Yulia Bortnyak

Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking

Chao Chen,Fei Luo,Hui Xu,Jianping Liu,Junchao Xue,Liang Zhou,Min Ling,Qian Bian,Qian Sun,Qizhan Liu,Xiangyu Dai,Yi Liu

Prostaglandin E2 hydrogel improves cutaneous wound healing via M2 macrophages polarization

Dashuai Zhu,Shuaiqiang Zhang,Xiaocang Cao,Xin Qi,Xin Zhang,Yihu Fang,Yongzhe Che,Yuanyuan Liu,Zhibo Han,Zhong-Chao Han,Zongjin Li,Zuo-Xiang He

“Cell-addictive” dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway

Hong Qing,LiQun Zhang,LinYing Liu,QingHu Yang,Xin Zhang,YanHui Li,ZhaoTan Jiang,ZhiGuo Lu,ZiXuan Chen

Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production

Adriaan A. Voors,Alexandre Mebazaa,Arnold Piek,Cees W.A. van de Kolk,Christian Mueller,E. Marloes Schouten,Herman H.W. Silljé,Rudolf A. de Boer,Weijie Du

Pharmacokinetics and biodistribution of polymeric micelles containing miRNA and small-molecule drug in orthotopic pancreatic tumor-bearing mice

Chalet Tan,Ram I. Mahato,Vaibhav Mundra,Virender Kumar,Yang Peng,Yingzhe Wang

Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors

Chenyang Zhao,Huiyan Luo,Jie Liu,Na Sun,Rui Cheng,Xian Li,Ya Chen,Zerong Liu,Zhe Yang,Zhongmin Tian

Label-free imaging of hemoglobin degradation and hemosiderin formation in brain tissues with femtosecond pump-probe microscopy

Bohan Zhang,Jiayi Zhang,Liang Chen,Lili Zhang,Liyuan Cui,Minbiao Ji,Xiang Zou,Ying Mao

Flufenamic acid inhibits secondary hemorrhage and BSCB disruption after spinal cord injury

Dan Zhu,Jianyi Xu,Jiedong Wang,Tingting Yu,Yingtao Yao,Yiqiang Hu,Yongchao Wu,Zhilong Chen,Zhiyong Xiao

Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-based diagnosis and chemotherapy of metastatic cancer

Eun-Joo Park,Hohyeon Lee,Hyejin Jang,Hyun Jung Kim,Hyuncheol Kim,Suhyun Park,Yongho Jang

WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma

Afonso A. Pinto,Bruno M. Costa,Carlos Clara,Carlos Custódia,Cláudia C. Faria,Céline S. Gon？alves,Eduarda P. Martins,Emmanuel Chautard,Fernando Pardal,Joana Vieira de Castro,Manuel Melo Pires,Marta Pojo,Nuno Sousa,Ricardo Taipa,Rui M. Reis,Sandro Queirós

Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis

Bo Youn Choi,Dong Hoon Hyun,Dong-Gyu Jo,Gahee Bahn,Hark Kyun Kim,Jae Hoon Sul,Jae Hyung Park,Jeung-Whan Han,Jihoon Han,Jin Su Park,Jong-Sung Park,Li-Jung Kang,Sang-Ha Baik,Seung Hyun Baek,Siyoung Yang,Thiruma V. Arumugam,Yong-Woo Cho,Yoonsuk Cho,Young Mo Kang,Yuri Choi

Senescent fibroblasts drive ageing pigmentation: ？A potential therapeutic target for senile lentigo

Hee Young Kang,Jang-Hee Kim,Jung Eun Yoon,Misun Kim,Soohyun Kwon,Tae Jun Park,Yeongeun Kim,Young Hwa Kim

Dopaminergic precursors differentiated from human blood-derived induced neural stem cells improve symptoms of a mouse Parkinson's disease model

Jing An,Shuyan Wang,Xihe Tang,Y. Alex Zhang,Yanchuan Wu,Yanpeng Yuan,Yun-Fei Bai,Zhi-Qing David Xu,Zhiguo Chen

Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis

Cong Cao,Jian Sun,Jin Yao,Ke-ran Li,Qin Jiang,Qing Yu,Shuo-fei Yang,Wei Huang,Xiao-pei Zhang,Zhi-qing Zhang

Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy

Chul Soon Yong,Han-Gon Choi,Jae-Hoon Chang,Jong Oh Kim,Kishwor Poudel,Liyuan Jiang,Raj Kumar Thapa,Sae Kwang Ku,Wenquan Ou,Zar Chi Soe

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches

Eyleen Araya-Fuentes,Francisco Morales-Zavala,Hugo E. Verdejo,Ivonne Garcia-Carvajal,Javier O. Morales,Julian Bejarano,Marcelo J. Kogan,Mario Navarro-Marquez,Pablo F. Castro,Sergio Lavandero,Yvo Flores

MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain

Bobbi K Lewis,Farhan Qureshi,Joseph A Frank,Maggie Sundby,Neekita Jikaria,Scott R Burks,Tsang-Wei Tu,Zsofia I Kovacs

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling

Claudio de Lucia,Douglas G. Tilley,Erhe Gao,Jeffrey L. Benovic,Laurel A. Grisanti,Rhonda L. Carter,Toby P. Thomas,Walter J. Koch

Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI

Adam E. Hansen,Andreas Kj？r,Axel Haase,Benedikt Feuerecker,Christian Hundshammer,Christoph A. Müller,Franz Schilling,Jan-Bernd H？vener,Jorge Cabello,Katja Steiger,Markus Schwaiger,Mathias Schillmaier,Miriam Braeuer,Steffen J. Glaser,Stephan Düwel,Stephan G. Nekolla,Wilko Weichert

Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma

Bowen Yao,Changwei Dou,Kangsheng Tu,Liang Wang,Liankang Sun,Meng Xu,Qing Li,Qingguang Liu,Wei Yang,Yufeng Wang,Zhikui Liu

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