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BMC Pharmacology

ISSN Print: 1471-2210

ISSN Online:

主页: http://www.biomedcentral.com/bmcpharmacol/

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5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved

Davis Robert,Pattison Jill,Thompson Janice M,Tiniakov Ruslan

Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors

Cuppoletti John,Blikslager Anthony T,Chakrabarti Jayati,Nighot Prashant K

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Munro Thomas A,Berry Loren M,Van’t Veer Ashlee,Béguin Cécile

Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor

Wang Aiying,Dorso Charles,Kopcho Lisa,Locke Gregory

Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation

Aaltonen Niina,Lehtonen Marko,Varonen Katri,Goterris Gemma

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency

Kammermeier Paul J

Novel olanzapine analogues presenting a reduced H1 receptor affinity and retained 5HT2A/D2 binding affinity ratio

Jafari Somayeh,Bouillon Marc E,Huang Xu-Feng,Pyne Stephen G

Computational models for in-vitro anti-tubercular activity of molecules based on high-throughput chemical biology screening datasets

Periwal Vinita,Kishtapuram Shireesha,,Scaria Vinod

A web server for predicting inhibitors against bacterial target GlmU protein

Singla Deepak,Anurag Meenakshi,Dash Debasis,Raghava Gajendra PS

Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors

Durrant Jacob D,McCammon J Andrew

Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice

Chia Elizabeth,Kagota Satomi,Wijekoon Enoka P,McGuire John J

Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors

Hayase Tamaki

Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells

Alli Elizabeth,Sharma Vandana B,Hartman Anne-Renee,Lin Patrick S

Dexamethasone restrains ongoing expression of interleukin-23p19 in peripheral blood-derived human macrophages

Palma Linda,Sfara Carla,Antonelli Antonella,Magnani Mauro

Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice

Moya Pablo R,Fox Meredith A,Jensen Catherine L,Laporte Justin L

Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo

Kudo Chieko,Yamakoshi Hiroyuki,Sato Atsuko,Nanjo Hiroshi

The boron-oxygen core of borinate esters is responsible for the store-operated calcium entry potentiation ability

Dellis Olivier,Mercier Pierre,Chomienne Christine

The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen

Stahl Jessica,Wohlert Mareike,Kietzmann Manfred

Amphetamine actions rely on the availability of phosphatidylinositol-4,5-bisphosphate

Buchmayer Florian,Schicker Klaus,Stübiger Gerald,Hamilton Peter J

Comparison of different vasodilators, endothelin antagonist, PDE5 inhibitior and sGC stimulators, in an animal model of secondary pulmonary hypertension: effects on “desaturation”

Becker Eva,Stasch Johannes-Peter,Bechem Martin,Truebel Hubert

Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

Wan Tina C,Tosh Dilip K,Du Lili,Gizewski Elizabeth T

Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro

Dimpfel W,Hoffmann JA

Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?

Bianchi Matt T,Botzolakis Emmanuel J

Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources

Asami Yukihiro,Horie Ryo,Hamamoto Hiroshi,Sekimizu Kazuhisa

An evaluation of R2 as an inadequate measure for nonlinear models in pharmacological and biochemical research: a Monte Carlo approach

Spiess Andrej-Nikolai,Neumeyer Natalie

Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole

Ferrari-Toninelli Giulia,Maccarinelli Giuseppina,Uberti Daniela,Buerger Erich

Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia

Wang Che-Chuan,Chio Chung-Ching,Chang Ching-Hong,Kuo Jinn-Rung

Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells

Tang Leilei,Bergevoet Saskia M,Gilissen Christian,de Witte Theo

Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice

Lim Adeline YL,Segarra Ignacio,Chakravarthi Srikumar,Akram Sufyan

Endogenous dynorphin in emotional control and stress response revisited

Schwarzer Christoph,Lutsch Christian,Schunk Eduard,Kastenberger Iris

BIAdb: A curated database of benzylisoquinoline alkaloids

Singla Deepak,Sharma Arun,Kaur Jasjit,Panwar Bharat

Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study

García-García Idrian,González-Delgado Carlos A,Valenzuela-Silva Carmen M,Díaz-Machado Alina

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

Srilaxmi Polimetla,Sareddy Gangadhara,kishor Polavarapu,Setty Oruganti

Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling

Jiang Baohong,Chen Jing,Xu Lingling,Gao Zhenting

Amphetamine Dependence and Co-Morbid Alcohol Abuse: Associations to Brain Cortical Thickness

Lawyer Glenn,Bjerkan Petr S,Hammarberg Anders,Jayaram-Lindstr？m Nitya

Antinociceptive effect of geranylgeraniol and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester isolated from Pterodon pubescens Benth

Spindola Humberto M,Servat Leila,Denny Carina,Rodrigues Rodney AF

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) Receptor Antagonist

Hadcock John R,Carpino Philip A,Iredale Philip A,Dow Robert L

Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule

Mishra Nitish K,Agarwal Sandhya,Raghava Gajendra PS

Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands

Davis Christopher N,Bradley Stefania,Schiffer Hans H,Friberg Mikael

AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts

Adamo Luigi,Zhang Yuzhi,García-Carde？a Guillermo

Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells

Jiang Lin,Saetre Peter,Jazin Elena,Carlstr？m Eva

Cardioprotective effects of bilberry extract on ischemia-reperfusion-induced injury in isolated rat heart

？iberna Lovro,Lunder Mojca,Mo？e ？pela,Vanzo Andreja

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

Roof Rebecca A,Roman David L,Clements Samuel T,Sobczyk-Kojiro Katarzyna

Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models

Lee Nancy,Woodrum Chelsey L,Nobil Alison M,Rauktys Aubrey E

Bioinformatic characterizations and prediction of K+ and Na+ ion channels effector toxins

Soli Rima,Kaabi Belhassen,Barhoumi Mourad,El-Ayeb Mohamed

Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells

Vik-Mo Audun O,Fern？ Johan,Skrede Silje,Steen Vidar M

Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway

Lu Desheng,Carson Dennis

Conformational changes in α7 acetylcholine receptors underlying allosteric modulation by divalent cations

McLaughlin James T,Barron Sean C,See Jennifer A,Rosenberg Robert L

An efficient drug delivery vehicle for botulism countermeasure

Zhang Peng,Ray Radharaman,Singh Bal,Li Dan

Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity

Portugal José

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