Molecular Neurodegeneration - oalib

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Molecular Neurodegeneration

ISSN Print: 1750-1326

ISSN Online:

主页: http://www.molecularneurodegeneration.com

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In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures

Perez Pablo D,Hall Gabrielle,Kimura Tetsuya,Ren Yan

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Qiu Linghua,Qiao Tao,Beers Melissa,Tan Weijia

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

Eimer William A,Vassar Robert

Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression

Cronin-Furman Emily N,Borland M Kathleen,Bergquist Kristen E,Bennett James P

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

Julie Brodeur, Caroline Thériault, Mélissa Lessard-Beaudoin, Alexandre Marcil, Sophie Dahan, Christine Lavoie

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

Robert Tamayev, Luciano D'Adamio

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

Tatsunori Maekawa, Sayuri Mori, Yui Sasaki, Takashi Miyajima, Sadahiro Azuma, Etsuro Ohta, Fumiya Obata

Does a loss of TDP-43 function cause neurodegeneration?

Zuoshang Xu

Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome

Zhao-hui Xu, Qi Yang, Bin Feng, Shui-bing Liu, Nan Zhang, Jiang-hao Xing, Xiao-qiang Li, Yu-mei Wu, Guo-dong Gao, Ming-gao Zhao

Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andrés Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo, Francisca C Bronfman

Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach

Carole J Proctor, Ilse Sanet Pienaar, Joanna Elson, Thomas BL Kirkwood

Progranulin regulates neuronal outgrowth independent of Sortilin

Jennifer Gass, Wing C Lee, Casey Cook, Nicole Finch, Caroline Stetler, Karen Jansen-West, Jada Lewis, Christopher D Link, Rosa Rademakers, Anders Nykj？r, Leonard Petrucelli

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Yonghao Zhao, Yunshu Wang, Jiaye Yang, Xin Wang, Yingjun Zhao, Xian Zhang, Yun-wu Zhang

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology

Nicole L Bjorklund, Lindsay C Reese, V-M. Sadagoparamanujam, Valeria Ghirardi, Randall L Woltjer, Giulio Taglialatela

A molecular signature in blood identifies early Parkinson’s disease

Leonid Molochnikov, Jose M Rabey, Evgenya Dobronevsky, Ubaldo Bonucelli, Roberto Ceravolo, Daniela Frosini, Edna Grünblatt, Peter Riederer, Christian Jacob, Judith Aharon-Peretz, Yulia Bashenko, Moussa BH Youdim, Silvia A Mandel

Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons

Xin Heng, Gang Jin, Xin Zhang, Dehuang Yang, Mingzhe Zhu, Shijun Fu, Xuping Li, Weidong Le

Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases

Cheng Fang, Dennis Bourdette, Gary Banker

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine, Marie-Fran？oise Chesselet

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo, W Blaine Stine, Sara-Claude Michon, Evelyn Nwabuisi-Heath, Arlene M Manelli, Yifan Fu, Sean Riordan, William A Eimer, Lester Binder, Guojun Bu, Chunjiang Yu, Dean M Hartley, Mary Jo LaDu

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

Jin Chu, Phillip F Giannopoulos, Carolina Ceballos-Diaz, Todd E Golde, Domenico Pratico

Rapid glutamate receptor 2 trafficking during retinal degeneration

Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell, Robert E Marc

FE65 as a link between VLDLR and APP to regulate their trafficking and processing

Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn, Young Jin Lee, Suzanne Y Guénette, Toshiharu Suzuki, Paul M Mathews, Daniel TS Pak, G William Rebeck, Yoo-hun Suh, Hee-Sae Park, Hyang-Sook Hoe

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen

Spinal cord trauma and the molecular point of no return

Ping K Yip, Andrea Malaspina

Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult

Shaefali P Rodgers, Heather A Born, Pritam Das, Joanna L Jankowsky

Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system

Victor Tulio Ribeiro de Resende, Alvaro Carrier-Ruiz, Robertha M R Lemes, Ricardo A M Reis, Rosalia Mendez-Otero

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dachsel, Sarah J Lincoln, Erin E Bowles, Joel E Beevers, Brittany N Dugger, Caroline B Kent, Beate Winner, Iryna Prots, Kenya Nishioka, Wenlang Lin, Dennis W Dickson, Christopher G Janus, Matthew J Farrer, Heather L Melrose

Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia

Yanyan Sun, Yu Zhang, Xiaoyang Wang, Klas Blomgren, Changlian Zhu

Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS

Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, Jianhang Jia

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W Patterson, Randall J Bateman, David M Holtzman

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects

Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne M Fagan, David M Holtzman, Randall Bateman, Hamid R Sohrabi, Ralph N Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki

Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease

Keizo Sugaya, Shiro Matsubara

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity

Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins

Regulation of mitochondrial permeability transition pore by PINK1

Clement A Gautier, Emilie Giaime, Erica Caballero, Lucía Nú？ez, Zhiyin Song, David Chan, Carlos Villalobos, Jie Shen

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng, Wei Wu, Rong Hu, Or Hadass, Tareq Lehmidi, Gregory J Blair, Mijoon Lee, Mayland Chang, Shahriar Mobashery, Grace Y Sun, Zezong Gu

WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity

Jo Ann V Antenor-Dorsey, Karen L O'Malley

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Rasool Suhail,Albay Ricardo,Martinez-Coria Hilda,Breydo Leonid

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Inoue Keiichi,Rispoli Joanne,Kaphzan Hanoch,Klann Eric

Formononetin could increase soluble-APPα secretion by up-regulating ADAM10 level

Zhou Ting,Shun Miao,Zhou Liang,Yang Huan

Regulated protein aggregation: stress granules and neurodegeneration

Wolozin Benjamin

Testosterone regulates Arp2/3 expression by DNA methylation in hippocampus

Zhou Liang,Zhang Ximeng,Wu Xuefei,Yang Huan

Identification of BACE2 as an avid -amyloid-degrading protease

Abdul-Hay Samer O,Sahara Tomoko,McBride Melinda,Kang Dongcheul

Molecular mechanisms for simvastatin-mediated enhancement of synaptic plasticity

Mans Robert A,McMahon Lori L,Li Ling

Application of bimolecular fluorescence complementation in studying the topology of polytopic proteins

Chang Xingya,Dou Fei

Implication of lipid metabolism disturbance and Alzheimer’s disease: focus on the lipoprotein lipase plays an important role in learning and memory function

Chui Dehua,Zhou Ting,Zhou Liang,Yang Huan

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Danzer Karin M,Kranich Lisa R,Ruf Wolfgang P,Cagsal-Getkin Ozge

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

Martinez Terina N,Chen Xi,Bandyopadhyay Sibali,Merrill Alfred H

Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons

Franco Carolina,Fernández Silvia,Torres-Alemán Ignacio

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