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ISSN: 2333-9721
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BMC Chemical Biology

ISSN Print: 1472-6769

ISSN Online:

主页: http://www.biomedcentral.com/bmcchembiol

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Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen

Tong Shi, Ju Bao, Nick X Wang, Jie Zheng, Dianqing Wu

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

Teodora Pene-Dumitrescu, Sherry T Shu, Thomas E Wales, John J Alvarado, Haibin Shi, Purushottam Narute, Jamie A Moroco, Joanne I Yeh, John R Engen, Thomas E Smithgall

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications

Hiroki Kobayashi, Hiroko Harada, Masaomi Nakamura, Yushi Futamura, Akihiro Ito, Minoru Yoshida, Shun-ichiro Iemura, Kazuo Shin-ya, Takayuki Doi, Takashi Takahashi, Tohru Natsume, Masaya Imoto, Yasubumi Sakakibara

High toxicity and specificity of the saponin 3-GlcA-28-AraRhaxyl-medicagenate, from Medicago truncatula seeds, for Sitophilus oryzae

Pedro Da Silva, Vanessa Eyraud, Ma？té Carre-Pierrat, Catherine Sivignon, Isabelle Rahioui, Corinne Royer, Frédéric Gressent

Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives

Sadashiva Maralinganadoddi,Basappa,NanjundaSwamy Shivananju,Li Feng

Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound

Indra Sandal, Amita Bhattacharya, Uksha Saini, Devinder Kaur, Shveta Sharma, Ashu Gulati, Jonnala K Kumar, Neeraj Kumar, Jyotsna Dayma, Pralay Das, Bikram Singh, Paramvir S Ahuja

Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites

Fazlurrahman Khan, Dhan Prakash, RK Jain

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1

Fengfeng L Xu, Youssef Rbaibi, Kirill Kiselyov, John S Lazo, Peter Wipf, William S Saunders

The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds

Nicolas Puillandre, Mand？ Holford

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

Courtney R LaValle, Karla Bravo-Altamirano, Karthik V Giridhar, Jun Chen, Elizabeth Sharlow, John S Lazo, Peter Wipf, Q Jane Wang

Dietary phenethylisothiocyanate attenuates bowel inflammation in mice

Moul Dey, Peter Kuhn, David Ribnicky, VummidiGiridhar Premkumar, Kenneth Reuhl, Ilya Raskin

MyD88-dependent and independent pathways of Toll-Like Receptors are engaged in biological activity of Triptolide in ligand-stimulated macrophages

Vummidigiridhar Premkumar, Moul Dey, Ruth Dorn, Ilya Raskin

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

Charles Evans, Katrina L Bogan, Peng Song, Charles F Burant, Robert T Kennedy, Charles Brenner

Chemical-genetic profile analysis of five inhibitory compounds in yeast

Md Alamgir, Veronika Erukova, Matthew Jessulat, Ali Azizi, Ashkan Golshani

Local and global modes of drug action in biochemical networks

Jean-Marc Schwartz, Jose C Nacher

Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue

Patrick Chène, Jo？lle Rudloff, Joseph Schoepfer, Pascal Furet, Peter Meier, Zhiyan Qian, Jean-Marc Schlaeppi, Rita Schmitz, Thomas Radimerski

Chemical tools selectively target components of the PKA system

Daniela Bertinetti, Sonja Schweinsberg, Susanne E Hanke, Frank Schwede, Oliver Bertinetti, Stephan Drewianka, Hans-Gottfried Genieser, Friedrich W Herberg

Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

Jianwen Fang, Yakov M Koen, Robert P Hanzlik

Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus

John Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie Bélanger, Lubica Supekova, Andrew I Su

DG-AMMOS: A New tool to generate 3D conformation of small molecules using Distance Geometry and Automated Molecular Mechanics Optimization for in silico Screening

David Lagorce, Tania Pencheva, Bruno O Villoutreix, Maria A Miteva

Glycosylated VCAM-1 isoforms revealed in 2D western blots of HUVECs treated with tumoral soluble factors of breast cancer cells

Delina Montes-Sánchez, Jose Ventura, Irma Mitre, Susana Frías, Layla Michán, Aurora Espejel-Nu？ez, Felipe Vadillo-Ortega, Alejandro Zentella

Chemogenetic fingerprinting by analysis of cellular growth dynamics

Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg

Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae

Lorena Norambuena, Jan Zouhar, Glenn R Hicks, Natasha V Raikhel

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II

Maria Olofsson, Aleksandra Havelka, Slavica Brnjic, Maria C Shoshan, Stig Linder

The effect of amino acid deletions and substitutions in the longest loop of GFP

Gabriela Flores-Ramírez, Manuel Rivera, Alfredo Morales-Pablos, Joel Osuna, Xavier Soberón, Paul Gaytán

Enhancement of intracellular γ-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation

Yuichiro Tanaka, Leslie Wood, Robert V Cooney

Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator

Justin J Heynekamp, Lucy A Hunsaker, Thomas A Vander Jagt, Lorraine M Deck, David L Vander Jagt

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

Zoltan Maliga, Timothy J Mitchison

Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine

Ahmed Abdullah, Fazlul Huq, Ashraf Chowdhury, Hasan Tayyem, Philip Beale, Keith Fisher

Covalent attachment of the plant natural product naringenin to small glass and ceramic beads

Yuhua Lu, Niloufer G Irani, Erich Grotewold

Development of ERK Activity Sensor, an in vitro, FRET-based sensor of Extracellular Regulated Kinase activity

Harry M Green, José Alberola-Ila

Electronic properties of amino acid side chains: quantum mechanics calculation of substituent effects

Donard S Dwyer

Redesigned and chemically-modified hammerhead ribozymes with improved activity and serum stability

Philip Hendry, Maxine J McCall, Tom S Stewart, Trevor J Lockett

An informatics search for the low-molecular weight chromium-binding peptide

Deendayal Dinakarpandian, Vincent Morrissette, Shveta Chaudhary, Kambiz Amini, Brian Bennett, J David Van Horn

Chemical cleavage reactions of DNA on solid support: application in mutation detection

Chinh T Bui, Andreana Lambrinakos, Jeffrey J Babon, Richard GH Cotton

Synthesis and cytotoxicity of a biotinylated CC-1065 analogue

Yuqiang Wang, Huiling Yuan, Susan C Wright, Hong Wang, James W Larrick

Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug

Yuqiang Wang, Huiling Yuan, Susan C Wright, Hong Wang, James W Larrick

Analysis of fluorescently labeled substance P analogs: binding, imaging and receptor activation

Vicki J Bennett, Mark A Simmons

Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study)

Ami Lakdawala, Minmin Wang, Neysa Nevins, Dennis C Liotta, Danuta Rusinska-Roszak, Marek Lozynski, James P Snyder

Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement

James M Varnum, Janina Baraniak, Renata Kaczmarek, Wojciech J Stec, Charles Brenner

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