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Feb 22, 2021Open    AccessArticle

Dose Load during Orthopedic Procedures

Natasha Ivanova, Javor Ivanov, Marin Marinov, Miroslav Petrov
This article discusses the dose load of people working with a C-arm X-ray system during orthopedic procedures. We measured the effective doses received by the doctor-operator and his assistant at three points of the body—head, gonads and feet, in radiography mode (single shot) and in three sub-modes of the fluoroscopy mode—continuous fluoroscopy; 1/2 dose fluoroscopy and pulse fluoroscopy. Calculations were made for dose rate the resulting our measurements due to the fact that at the different e...
Open Access Library J. Vol.8, 2021
Doi:10.4236/oalib.1107107


Nov 27, 2020Open    AccessArticle

Non-Clinical Factors Associated with International Normalized Ratio Control in Patients on Warfarin Therapy: A Review Paper

Tharani Ramasamy, Naganathan Kathiresan Pillai, Christina Gertrude Yap, Nowrozy Kamar Jahan
Warfarin is a coumarin derivative oral anticoagulant with a narrow therapeutic international normalized ratio (INR) range. Regular and accurate INR monitoring is essential for optimal anticoagulation management and to reduce the risk of adverse events. However, achieving and maintaining the therapeutic INR range are still a challenge as it is affected by several clinical and non-clinical factors. In this review paper, we analyzed how the non-clinical factors like socio-demographic, modifiable ri...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106947


Jul 08, 2020Open    AccessArticle

Non-Carcinogenic Genotoxic Drugs Could Be Used to Prevent and Treat COVID-19

Gao-De Li
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106536


May 15, 2020Open    AccessArticle

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

Gao-De Li
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106340


Sep 26, 2019Open    AccessArticle

Pharmacognostical Study of the Fruit Peels of Punica granatum

Rofidah Yasen Ahmed Diab, Ahlam Salih Eltahir
This study deals with Punica granatum fruit peels. This plant was selected because of its popularity and being highly used; it was purchased from herbarium markets of Khartoum Sudan. The study is divided into two parts, the
...
Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105687


Mar 27, 2019Open    AccessArticle

Pharmacognostic, Physicochemical and Phytochemical Analysis of Fruits of Talipariti elatum (Sw.) in Cuba

José González, Julio Pérez, Armando Cuéllar, Enrique Gómez, Yamilet I. Gutiérrez, Ramón Scull, Damaris de la C. Salgado, Max Monan
Talipariti elatum (Sw.) Fryxell is an endemic tree from Cuba, also known as “Majagua”, and has traditionally been used to improve asthmatic crisis and flu, as expectorant, appetitive, emollient, sudorific and laxative. Used as ornamental in park and avenues, its wood is used to make furnitures and baseball baths. In order to offer aspects related to the quality and effectiveness of the plant, its pharmacognostic, physicochemical,
...
Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105300


Dec 29, 2018Open    AccessArticle

Antimicrobial Activities of Syzygium aromaticum (L.) Merr. and L.M. Perry (Myrtaceae) Fruit Extracts on Six Standard Microorganisms and Their Clinical Counterpart

Y.-G. Afanyibo, K. Anani, K. Esseh, Y. Sadji, K. Idoh, K. Koudouvo, A. Agbonon, Y. Améyapoh, K. Tozo, M. Gbeassor
Syzygium aromaticum is used in combination with other plants as an al-coholic infusion by traditional practitioners to treat infections. It has been selected for evaluation for its antimicrobial properties to justify its use in traditional pharmacopoeia. The fruits were used as plant material while the microbial germs consisted of six reference strains: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Salmonella typh
...
Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104951


Oct 26, 2018Open    AccessArticle

Pharmacognostical, Phytochemical and Antioxidant Evaluations of Guettarda calyptrata A. Rich.

Yamilet Irene Gutiérrez Gaitén, José González Yaque, Ramón Scull Lizama, Zuleira Ocanto Torres, Alejandro Felipe González, José Luis Mayoral Jiménez, Max Monan
Guettarda calyptrata A. Rich., originally from Cuba and known as “Contraguao”, has traditionally been used to counteract quickly and effectively burns produced by Comocladia dentate Jacq (Guao), vegetable species that secretes a highly caustic latex for skin and mucous membranes. A burn is a traumatic injury resulting in local and
...
Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104921


Jun 06, 2018Open    AccessArticle

Bioequivalence of 150 mg Extended-Release Ketoprofen from Laboratories LETI S.A.V. Test, vs ProfenidBI of Laboratories Sanofi-Aventis Pharmaceuticals LTDA, Prolonged Release, Reference, in Healthy Volunteers*

Maria A. Annunziato, Maria Gonzalez Yibirin, Inatti Alfredo, Maria M. Soler
Objective: To evaluate the bioequivalence between two formulations of ketoprofen after administration of a 150 mg extended release tablet (L.P. ProfenidBI?), 150 mg modified release tablets. Methods: A single-dose cross-over, randomized study was performed under fasting conditions with two treatments, two periods, two
...
Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104366


Feb 28, 2018Open    AccessArticle

Ciprofloxacin Hydrochloride Encapsulated into PLGA Nanoparticles for Drug Delivery Application: Fractional Factorial Design

Tajudeen Adebileje, Sikiru Adebileje, P. O. Aye
Over several decades, poly (lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and Nano-carriers of therapeutic agents for drug delivery applications. However, encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs) necessitates a defined step to understand the effects and interactions of parameters involved in production process. In pharmaceutics formulations, compared to
...
Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104294


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