Pantoprazole provides myocardial protection similar to ischemic preconditioning: experimental study of isolated hearts of rats

objective: to evaluate pantoprazole effect in the functional recovery of isolated hearts of rats, submitted to ischemia and reperfusion with and without ischemic preconditioning. methods: in four groups of eight wistar breed rats, the hearts were removed after anesthesia and perfused with krebs-henseleit solution (95% o2, 5% co2, 37oc). gi, gii, giii and giv hearts were submitted to ischemia (20 min) and reperfusion (30 min). in gii and giv, preconditioning was performed with 5 min of ischemia and 5 min of reperfusion before 20 min of the ischemia period induction. in giii and giv pantoprazole 100 mg was done before a 20 min-period of ischemia induction. heart rate (hr), coronary flow (cof), systolic pressure (sp), +dp/dt and -dp/dt were registered before (t0) and after reperfusion (t30). kruskal-wallis (p<0.05) test was used. results: there were no differences (p>0.05) between groups among hr and cof values. differences occurred between groups, i and ii, iii and iv at t30 with sp reduced for 32% mean value in gi, 65% gii, 65% giii, and 73% giv; the t30 + dp/dtmax were 34% in gi, 61% gii, 63% giii and 72% giv. the t30 -dp/dtmax were gi 28%, gii 63%, giii 75 % and giv 75%; (p<0.05). there were no significant differences in the sp, +dp/dtmax, and -dp/dtmax between groups ii, iii and iv results. conclusions: the administration of pantoprazole before induction of ischemia significantly protected the myocardial functional recovery with the results of sp, + dp / dtmax and dp/dtmax similar to the ischemic preconditioning against ischemia-reperfusion