Correlating the solubility of indomethacin in 1,4-dioxane + water mixtures by means of the Jouyban-Acree model

in this work the validity of the jouyban-acree and yalkowsky-roseman models is evaluated to correlate the solubility of indomethacin in 1,4-dioxane + water cosol- vent mixtures. the solubility correlation is studied as a function of temperature and cosolvent composition. both models require only the experimental solubility values in the pure solvents at all the temperatures evaluated. the solubility calculated values by using both models deviate notoriously from experimental values in several cases