Modificaciones del perfil hormonal sexual como resultado de la administración conjunta de dos sustancias que inhiben el metabolismo de la testosterona

this work aimed to see the effect on the sexual hormonal profile and in particular on the concentration of testosterone after administration of two different substances that block the mechanisms of its degradation. in addition check, using the technique of stable isotopes (gc-c-irms), if the testosterone that accumulates in the body by these inhibitions is due simply to the blocking of the mechanisms of degradation or any of the compounds administered go into the route as a metabolic precursor to increase its production. to accomplish this we studied the effects that initially had the aromatase inhibitor 3, 6, 17 androstenetriona (6-oxo) on the sexual hormonal profile of two healthy volunteers and confirmed, by the isotopic analysis, that this substance participate in the road testosterone production by studying its major metabolites of excretion: androsterone and ethiocholanolone. subsequently we studied the effect of the administration of this inhibitor in combination with an inhibitor of cytochrome p-450 (6 ′, 7′, dihidroxibergamotin-dhb) in two other volunteers. in both experiments showed an increase in the hormonal profile especially in the concentration of dehydroepiandrosterone (dhea) and testosterone, explaining the reason of why such mixtures are promoted to increase muscle mass and thus the physical appearance.