Presencia del alelo T para el polimorfismo rs2781666 G>T del gen arginasa 1 constituye un factor protector contra enfermedad arterial coronaria

background: recent data support a role for arginase 1 (arg1) in the initiation, development, and compli-cations of coronary artery disease. thus, in the present study we investigated the possible association between the rs2781666 g>t variant of arg1 and the presence of cad confirmed by angiography in chilean subjects. methods: a total of 124 unrelated patients with diagnosis of cad confirmed by angiography (stenosis > 70%) and 123 healthy controls (30 - 74 years oíd) were in-cluded in this study. the rs2781666 g>t variant of the arg1 gene was evaluated by pcr-rflr results: the frequency of tt homozygous genotype in cad patients was lower when compared to control group (6.5% vs. 8.0%, p=0.032). similarly, the t alíele frequency was different between cad and control groups (0.230 vs. 0.325, p=0.031). the or for cad related to t alíele was 0.64 (95%ci. = 0.43-0.94), con-firming the association founded. conclusión: these findings suggest that the t alíele for rs2781666 polymorphism of the arg1 gene constitutes an inherited protective factor against cad in southern chilean subjects.