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Relación entre la hiperglicemia al ingreso a la unidad de emergencia y el pronóstico en pacientes no diabéticos con infarto agudo al miocardio, no sometidos a terapia de reperfusión

DOI: 10.4067/S0718-85602012000100003

Keywords: hyperglycemia, prognosis, myocardial infarction.

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Abstract:

background: only in recent years attention has been paid to the relationship between hyperglycemia and the increased morbidity and mortality of acute myo-cardial infarction. numerous studies have described this association in patients with type 2 diabetes mellitus. however, there are few studies in patients without previously diagnosed type 2 diabetes. aim: to determine the relationship between hyper-glycemia on admission (ih) and prognosis in patients admitted with acute st elevation myocardial infarction who had no history of dm2 and did not undergo reper-fusion therapy (primary angioplasty and/or thrombolysis). method: we performed a retrospective study that included a cohort of 230 patients admitted to the emergency unit of the hospital carlos van buren with acute st elevation myocardial infarction from 2008 through 2009 who had a blood glucose test done at admission. patients were divided into two groups according to whether or not they were hyperglycemic. we used a composite outcome that included death, re-infarction, coronary cause of rehospitalization, need for coronary angiography and revascularization. we also evaluated each of its components separately. results: the composite event rate was 31.9% in patients with ih vs 27.6% in patients without ih (p=0.05). respective mortality rates were 11% and 0.8% (p<0.001), with a rr of 13.3 (ci 1.7 - 100.7) and lr 12.7. re infarction occurred in 4 patients, all of them with ih (p=0.034, lr 6) conclusion: hyperglycemia on admission was found to be an important marker of short term morbidity and mortality in patients with st elevation myocardial infarction and no prior diagnosis of diabetes.

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