Patología de las malformaciones del desarrollo cortical en pacientes con epilepsia refractaria: Experiencia en un hospital pediátrico

malformations of cortical development (mcd) comprise a heterogeneous group of lesions characterized by a disruption of the normal architecture of the cerebral cortex, ranging from subtle microscopic lesions to large lesions that can compromise an entire hemisphere or shape defined genetic syndromes. multiple classification schemes have been proposed to catalogue patients with developmental malformations in subgroups based on criteria and pathological images. but even now, literature is very confusing in their classification and / or the criteria used to assess reproducibility. in some cases it may be difficult to distinguish these lesions from a tumor (ganglioglioma or dysembryoplastic neuroepithelial tumor) for the possible coexistence of both lesions and representativeness of the samples. the use of human tissue for surgical resection provides a fundamental tool both to clarify the pathogenesis and for future research. our experience in pathology of epilepsy associated with malformations of the development over 20 years in a public pediatric hospital includes temporal lobe and extra-temporal pathology, pure malformations, dual pathology and other associations.