Rash y anemia aplásica inducidos por fenitoína: caso clínico

rash is a common side effect associated with antiepileptic drugs. the rate of a phenytoin rash is 5.9% and increases to 25% in those with another antiepileptic drug rash. aplastic anemia is an adquired hematopoietic stem-cell disorder characterized by pancytopenia of the peripheral blood and hypocellular bone marrow. the use of phenytoin is associated with a 3.5 fold increased risk of aplastic anemia. we report a case of a 70-year-old woman who developed two severe adverse reactions simultaneously with phenytoin: a maculopapular pruritic rash with involvement of mucous and an aplastic anemia. both conditions normalized after phenytoin withdrawal.