CAPACIDAD PROTECTORA CONFERIDA A LAS CRíAS POR ANTICUERPOS MATERNOS INDUCIDOS POR UN CANDIDATO VACUNAL DE SUBUNIDAD PROTEICA (E2)

four groups of pigs of 34 days old were conformed in order to evaluate the protective capacity conferred for maternal antibodies to offspring from mothers vaccinated with a vaccine candidate of protein subunit e2, against classical swine fever virus (csfv), obtained for adenoviral vector transduced to the mammary gland of goats, against challenge with a highly pathogenic strain (margarita) at doses of 104 pid50 (infective doses 50% pigs). groups 1 and 2 were conformed by five pigs with passively transferred maternal antibodies from mothers vaccinated with a vaccine candidate of protein subunit e2, and groups 3 and 4 (control groups ), conformed by three seronegative pigs to classical swine fever (csf), determined by neutralizing peroxidase linked assay (npla). the groups 1 and 3 were challenged by intranasal route and groups 2 and 4 by intramuscular route. the pigs with passively transferred maternal antibodies from mothers vaccinated and challenge by intranasal and intramuscular route were negative to viraemia and mortality; while those from the control groups were found sick and not protected for viraemia after challenge. the control group challenge for intramuscular route presented a smaller time of onset of the infectious process with respect to the group challenged by intranasal route.