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Terapia nutricional nas altera??es metabólicas em pessoas vivendo com HIV/aids

DOI: 10.1590/S0034-89102012005000050

Keywords: antiretroviral therapy, highly active, adverse effects, dietary supplements, utilization, hiv-associated lipodystrophy syndrome, diet therapy, dyslipidemias, diet therapy, hiv long-term survivors, review.

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Abstract:

objective: to analyze the effect of nutritional treatment on metabolic changes caused by the use of antiretroviral therapy in adults with hiv/aids. methods: a systematic review of literature was conducted in the pubmed, lilacs and cochrane databases, between 1996 and 2010, including crossover and randomized controlled clinical trials performed in adults with hiv/aids using antiretroviral therapy and without opportunistic diseases. the intervention of interest was oral nutritional supplementation and/or a change in lifestyle due to specific dietary treatment: dyslipidemia, insulin resistance, lipodystrophy and systemic arterial hypertension. the jadad scale was used for a qualitative classification of articles. results: a total of 385 articles were found, of which seven were included. the interventions used in these studies were as follows: diet, diet and physical exercises, diet and supplementation, and only supplementation. dyslipidemia was the outcome assessed in all studies. studies that assessed omega-3 supplementation found a significant reduction in triglycerides. the specific diet with omega-3 supplementation showed an increase in hdl-cholesterol. chrome nicotinate supplementation did not have an effect on dyslipidemia. changing one's lifestyle, including diet and physical activity, significantly reduced waist circumference, lipodystrophy and systolic blood pressure. conclusions: reduction in tryglicerides with omega-3 supplementation was the nutritional intervention with the strongest scientific evidence. prescribing a specific diet appeared to be the most adequate intervention to increase hdl-cholesterol. inferences could not be made about the nutritional treatment of total cholesterol, ldl-cholesterol and insulin resistance. changes in lifestyle can promote an improvement in lipodystrophy and blood pressure.

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