Administración del 8-OH-DPAT en el núcleo ventromedial hipotalámico: caracterización de la conducta alimentaria

the present study evaluated the effects of 5-ht1a receptor agonist 8-oh-dpat on the behavioral satiety sequence (bss) in rats. the 8-oh-dpat was administered via central in the hypothalamic ventromedial nucleus (vmn) in rats. the experimental subjects were kept under a dietary self-selection paradigm consisting of proteins, carbohydrates and fats. food and water were available all the time. intra-vmn administration of 5-ht1a agonist was associated with the selective increase in carbohydrate intake. the bss analysis revealed that the administration of 8-oh-dpat delayed the natural development of the bss. the results lead to the conclusion that 5-ht1a receptors in the nvh involved in the modulation of food intake, is discussed the possible involvement of interactions with other neurotransmitters systems.