Interac？？es medicamentosas entre a metadona e os anti-retrovirais

since 1965, methadone is a cornerstone in the therapy of opiate and opioid addiction. among injecting drug users (idu), individuals infected with human immunodeficiency virus (hiv) constitute a vulnerable population. despite the use of highly active antiretroviraltreatment (haart) in idus is possible and effective, several factors may adversely affect the treat-ment, including poor adherence to therapy, potential drug interactions between antiretroviral, methadone and illicit drugs, adverse effects and limited and often delayed access to antiretroviral treatment. drug interactions may potentiate the toxic effects of drugs, reduce the effectiveness of haart or trigger symptoms of opiate withdrawal, with subsequent relapse in opiate use and lower adherence to care and treatment regimens. the aim of this article is to present a literature？s review about drug interactions between methadone and antiretroviral drugs.