Síndrome DRESS inducido por fármacos anti tuberculosis

we present four patients with pulmonary tuberculosis and severe adverse reactions to antituberculosis drugs. these patients had skin rash, hepatitis, eosinophilia, fever, and one of them had renal failure; all these signs conform the diagnosis of dress syndrome. this syndrome is caused by a severe hypersensitivity reaction to different drugs. it is usually caused by anticonvulsants, sulfonamides, some antiviral drugs, among others drugs. anti-tuberculosis drugs can also cause this potentially fatal syndrome. the importance of surveillance for early detection and treatment of adverse drug reactions is emphasized.