Characterization of Liposomes for Cancer Cell Transfection

60-63 Svetlana A. Tatarkova and Satvinder Khaira Published Date: (26 October, 2007) We have characterized a broad range of liposome formulations with varying DcChol:DOPE ratio. Subsequent addition of DcChol to liposomes increases its positive surface charge. However, loading the nuclear acids did not neutralize the overall negative surface potential to a similar extent. The liposomes were tested by transfection of DNA in living cancer cells.