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Adenosine Kinase Expression Modulates Expression of Myelin Proteolipid ProteinDOI: 10.2174/1874082000701010015] Abstract: Adenosine is known to regulate myelination in vitro. Here we tested the hypothesis that adenosine, regulated by adenosine kinase (ADK), might regulate myelin-specific protein expression and myelination in vivo. We demonstrate that transgenic overexpression of ADK, which reduces adenosine in mouse brain, results in increased levels of myelin proteolipid protein.
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