Solvent free preparation of N-substituted maleanilic acid

Six N-maleanilic acids namely N-(4-carboxy)maleanilic acid (CAMAA), N-(4-bromo)maleanilic acid (BMAA), N-(4-hydroxy)maleanilic acid (HMAA), N-(3-hydroxy)maleanilic acid (mHMAA), N-(4-chloro)maleanilic acid (CMAA) and N-(4-methyl)maleanilic acid (MMAA) were prepared by solvent free reaction between maleic anhydride and a 4-carboxy, 4-bromo, 4-hydroxy, 3-hydroxy, 4-chloro and 4-methyl aniline derivatives in good to excellent yield. FT-IR, 1H-NMR and 13C-NMR spectra revealed the confirmation of these compounds in good agreement. KEYWORDS: Solvent free, Maleanilic acids, Maleic anhydride, Aniline derivatives Bull. Chem. Soc. Ethiop. 2013, 27(1), 137-141. DOI: http://dx.doi.org/10.4314/bcse.v27i1.15